• Name: Chang Yu, PhD, Assistant Professor, Director of Biostatistical Research, Generical Clinical Research Center, Vanderbilt University Medical Center
• Email: chang.yu@vanderbilt.edu
• Phone: (615)322-8422
• Fax: (615)343-4924
• Address:
  Vanderbilt University School of Medicine
  Department of Biostatistics
  S-2323 Medical Center North
  Nashville, TN 37232-2158

Experiences

• January 2004 to present, on the faculty of Department of Biostatistics
• June 1998 to December 2003, worked as a Biometrician/Senior Biometrician on multicenter clinical trials in the Clinical Biostatistics Department at Merck Research Laboratory, Rahway, New Jersey
• December 1995 to May 1998, worked as the biostatistician at Yale University School of Nursing, New Haven, CT

Research Interests

• Measurement Error Models
• Statistical Methods for Microarray Data Analysis
• Distributions and Methods on Correlated Binary Data
• Permutation Tests
• Sampling Methods
• Drug Efficacy and Safety Evaluation

Editorial Board

• Serve on the editorial board of Journal of Statistical Theory and Practice

Statistical Methods developed and implemented in a R package, Genetic Analysis Package

R functions: PFC and PFC.SIM at

http://www.maths.lth.se/help/R/.R/library/gap/html/00Index.html

Statistical Publications

Chang Yu, Sanguo Zhang, Chuan Zhou, and Saba Sile. A Likelihood Ratio Test of Population Hardy Weinberg Equilibrium for Case-Control Studies. Genetic Epidemiology (in press).

Wei Ning, Sanguo Zhang, Chang Yu. A Moment-based Test for the Homogeneity in Natural Exponential Family with Quadratic Variance Functions. Statistics & Probability Letters (in press).

Wei Ning, Arjun.K. Gupta, Chang Yu, Sanguo Zhang. A Moment-based Test for Homogeneity in Finite Mixture Models. Communications in Statistics: Theory and Methods (in press).

C. Yu and D. Zelterman. Sums of Exchangeable Bernoulli Random Variables for Family and Litter Frequency Data, Computational Statistics and Data Analysis 52:1636-49, 2008.

C. Yu and D. Zelterman. Sums of Dependent Bernoulli Random Variables and Disease Clustering, Statistics and Probability Letters, 57(4):363-373, 2002.

C. Yu and D. Zelterman. Statistical Inference for Familial Disease Clusters, Biometrics, 58(3)481-491, 2002.

O. Davidov and C. Yu. Stratified Double Sampling with Continuous Outcomes: Design and Analysis, Statistics, 36(2):163-173, 2002.

C. Yu and D. Zelterman. Exact Inference for Family Disease Clusters, Communications in Statistics: Theory and Methods, 30(11):2293-2305, 2001.

D. Zelterman and C. Yu. Multivariate Discrete Models for Longevity in Twins, The Institute for Mathematics and its Applications Volumes, Volume 114:131-140, Diagnosis and Prediction, Seymour Geisser(Editor), Springer-Verlag, 1999.

C. Yu, L. Waller, and D. Zelterman. Discrete Distributions for Use in Twin Studies, Biometrics 54:546-557, 1998.

S. Gupta, J. Goldstein, and C. Yu. Time Domain Estimation of Long Range Dependence, Journal of Information and Optimization Sciences, 18(3):493-498, 1997.

S. Gupta, J. Goldstein, and C. Yu. Fitting a Fractional ARIMA Model to Time Series Data, Journal of Information and Optimization Sciences, 17(3):467-483, 1996.

Collaborative Publications

Cyndya Shibao, Emily M. Garland, Alfredo Gamboa, Cindy L. Vnencak-Jones, Van M. Woeltz, Jonathan L. Haines, Chang Yu, and Italo Biaggioni. PRNP M129V? Homozygosity in Multiple System Atrophy vs. Parkinson's Disease, Clinical Autonomic Research (in press).

Christopher Baron, M.D., J. Herman Kan, M.D., Chang Yu, Ph.D., Marta Hernanz-Schulman, M.D. Utility of total lower extremity radiography investigation of non-weight bearing in the young child, Pediatrics (in press).

Saba Sile, Carlos G. Vanoye, Niloufar B. Gillani, Chang Yu, Loretta M. Byrne, James V. Gainer, Nancy J. Brown, Alfred L. George Jr. Lower Prevalence of Hypertension in African-Americans Carrying a Common BSND Variant, American Journal of Hypertension (in press).

J. Herman Kan, Bruce M. Damon, Chang Yu, Susan A. Connolly. MRI features of pediatric intra-articular tumors: a comparative study, _Clinical Radiology_(in press).

Haley CA, Cain KP, Yu C, Garman KF, Wells CD, Laserson KF. Epidemiology and Risk of Latent Tuberculosis Infection in Tennessee, Southern Medical Journal (in press).

Mias Pretorius, Brian S. Donahue, Chang Yu, James P. Greelish, Dan M. Roden, Nancy J. Brown. Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation Following Cardiopulmonary Bypass, _Circulation_(in press).

Allen S. Craig, Barbara Watson, Thomas K. Zink, Jeffrey P. Davis, Chang Yu, William Schaffner. Hepatitis A Outbreak Activity in the United States: Responding to a Vaccine-preventable Disease, The American Journal of the Medical Sciences (in press).

Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance, Clinical Pharmacology and Therapeutics 2007 May 23

I. Avalos, C.P. Chung, A. Oeser, G. Milne, J.D. Morrow, T. Gebretsadik, A. Shintani, C. Yu, C. M. Stein. Oxidative Stress in Systemic Lupus Erythematosus: relationship to disease activity and symptoms, Lupus (2007 Apr;16(3):195-200).

James M. Luther, James V. Gainer, Laine J. Murphey, Chang Yu, Douglas E. Vaughan, Jason Morrow, Nancy J. Brown. Angiotensin II Induces Interleukin-6 in Humans through a Mineralocorticoid Receptor-Dependent Mechanism, Hypertension 2006 Dec;48(6):1050-7.

Murff HJ, France DJ, Blackford J, Grogan EL, Yu C, Speroff T, Pichert JW, Hickson GB. Links Relationship between patient complaints and surgical Complications, Quality and Safety in Health Care 2006 Feb; 15(1):13-6.

L. B. Pupim, P. J. Flakoll, C. Yu, T. A. Ikizler. Recombinant Human Growth Hormone Improves Muscle Amino Acid Uptake and Whole-Body Protein Metabolism in Chronic Hemodialysis Patients, The American Journal of Clinical Nutrition 2005 Dec;82(6):1235-43.

Ma J, Albornoz F, Yu C, Byrne DW, Vaughan DE, Brown NJ. Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance. Hypertension 2005 Aug; 46(2):313-20.

D. R. Ramey, D. J. Watson, C. Yu, J.A. Bolognese, S.P. Curtis, A.S. Reicin. The incidence of upper gastrointestinal adverse events in clinical trials of etoricoxib vs. non-selective NSAIDs: an updated combined analysis. Current Medical Research and Opinion 2005 May;21(5):715-22.

DJ Watson, JA Bolognese, C Yu, D. Krupa, S Curtis. Use of gastroprotective agents and discontinuations due to dyspepsia with the selective cyclooxygenase-2 inhibitor etoricoxib compared with non-selective NSAIDs. Current Medical Research and Opinion 20(12):1899-1908, 2004.

Aharon AS, Mulloy MR, Drinkwater DC Jr, Lao OB, Johnson MD, Thunder M, Yu C, Chang P. Cerebral activation of mitogen-activated protein kinases after circulatory arrest and low flow cardiopulmonary bypass, European Journal of Cardiothoracic Surgery, 2004 Nov;26(5):912-9.

Watson, D.J., Bolognese, J.A., Yu C., Krupa, D.A., Curtis, S.P. Use of gastroprotective agents and discontinuations due to dyspepsia with the selective cyclooxygenase-2 inhibitor etoricoxib compared with non-selective NSAIDs, Current Medical Research and Opinion, 20(12):1899-1908, 2004.

DJ Watson, JA Bolognese, C Yu, D. Krupa, S Curtis. Use of gastroprotective agents and discontinuations due to dyspepsia with the selective cyclooxygenase-2 inhibitor etoricoxib compared with non-selective NSAIDs. Current Medical Research and Opinion 20(12):1899-1908, 2004.

R. Hunt, S. Harper, D. J. Watson, C. Yu, H. Quan, M. Lee, J. Evans, B. Oxenius. The Gastrointestinal Safety of the COX-2 Selective Inhibitor Etoricoxib Assessed by Both Endoscopy and Analysis of Upper Gastrointestinal Events, American Journal of Gastroenterology, 98(8):1725-1733, 2003.

R. Hunt, S. Harper, P. Callegari, C. Yu, H. Quan, J. Evans, C. James, B. Bowen, and R. Ferid. Complementary Studies of the Gastrointestinal Safety of the Cox-2 Selective Inhibitor Etoricoxib, Alimentary Pharmacology and Therapeutics, 17:201-210, 2002.

J. Zhang, C. Yu , S.T. Holgate, and T.F. Reiss. Variability and Lack of Predictive Ability of Asthma End-points in Clinical Trials, European Respiratory Journal, 20(5):1102-1109, 2002.

J. Zhang, C. Yu, G. Noonan, T.F. Reiss. Montelukast, a Once-daily Leukotriene Receptor Antagonist, Significantly Reduced Peak Expiratory Flow Variability, Clinical Therapeutics, 24:574-582, 2002.

A. B. Williams, C. Yu, K. Tashima, J. Burgess, and K. Danvers. Evaluation of Two Self-care Treatments for Prevention of Vaginal Candidiasis in Women with Human Immunodeficiency Virus Infection, Journal of the Association of Nurses in AIDS Care, 12(4):51-57, 2001.

Barnes N, Wei L X, Reiss T F, Leff J A, Shingo S, Yu C, and Edelman J M. Analysis of Montelukast in Mild Persistent Asthmatic Patients with Near-normal Lung Function, Respiratory Medicine 95: 379-386, 2001.

C. Lyder, C. Yu, J. Emerling, R. Mangat, D. Stevenson, O. Empleo-Frazier, and J. McKay. The Braden Scale for Pressure Ulcer Risk: Evaluating the Predictive Validity in Black and Latino/Hispanic Elders, Applied Nursing Research 12(2):60-68, 1999.

M. Grey, E.A. Boland, M. Davidson, C. Yu, and W.V. Tamborlan. Coping Skills Training for Youths with Diabetes on Intensive Therapy, Applied Nursing Research 12(1):3-12, 1999.

A. B. Williams, S. Andrews, K. Tashima, J. Mezger, C. Yu. Factors Associated with Vaginal Yeast Infections in HIV-Positive Women, Journal of the Association of Nurses in AIDS Care, 9(5):47-52, 1998.

M. Grey, E.A. Boland, C. Yu, S. Sullivan-Bolyai, & W.V. Tamborlane. Personal and Family Factors Associated with Quality of Life in Adolescents with Diabetes, Diabetes Care, 21(6):909-914, 1998.

M. Grey, E.A. Boland, M. Davidson, C. Yu, S. Sullivan-Bolyai, and W.V. Tamborlane. Short-Term Effects of Coping Skills Training as Adjunct to Intensive Therapy in Adolescents, Diabetes Care, 21(6):902-908, 1998.

C. Lyder, C. Yu, D. Stevenson, R. Mangat, O. Empleo-Frazier, J. Emerling, and J. McKay. Validating the Braden Scale for the Prediction of Pressure Ulcer Risk in Blacks and Latino/Hispanic Elders: A Pilot Study, Ostomy/Wound Management, 44(3A) Suppl:42s-50s, 1998.

C. Boult, M. Altmann, D. Gilbertson, C. Yu, and R.L. Kane. Decreasing Disability in the 21st Century: The Future Effects of Controlling Six Fatal and Nonfatal Conditions, American Journal of Public Health, 86:1388-93, 1996.

Memberships

• American Statistical Association
• Biometric Society (ENAR)
• Sino-American Pharmaceutical Professionals Association

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