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Yu Shyr, PhD

Ingram Professor of Cancer Research

Professor of Biostatistics

Director of Cancer Biostatistics Center

Vanderbilt-Ingram Cancer Center
Email:
   yu.shyr@vanderbilt.edu
Phone:
  615.936.2572
Fax:
  615.936.2602
 Vanderbilt University School of Medicine
Vanderbilt-Ingram Cancer Center
Department of Biostatistics
571 Preston Building
Nashville, TN 37232-6848

Biostatistics Shared Resource
Vanderbilt-Ingram Cancer Center

Research Interests

  • Consulting on biomedical problems, designing experiments and data analysis, clinical trials.
  • Applied multivariate analysis.
  • Applied statistical methods in modern molecular biology: RNA and Protein analysis.

Future Directions

Biography

Publications

  1. Calkins H, Shyr Y, Schork A, Kadish A, and Morady F: “Effects of Quinidine and Amiodarone on Blood-Pressure During Rapid Ventricular Pacing in Coronary-Artery Disease,” American Journal of Cardiology, 1992; 70(13): 1206-9.
  2. Levy S, Lauribe P, Dolla E, Kou W, Kadish A, Calkins H, Pagannelli F, Moyal C, Bremondy M, Schork MA, Shyr Y, Das S, Shea M, Gupta N, and Morady F: “A Randomized Comparison of External and Internal Cardioversion of Chronic Atrial Fibrillation,” Circulation, 1992; 86(5): 1415-20.
  3. Baliga P, Merion RM, Turcotte JG, Ham JM, Henley KS, Lucey MR, Schork A, Shyr Y, Campbell DA, Belzer FO, Gordon RD, Roseman DL, Wall WJ, and Boddie AW: “Preoperative Risk Factor Assessment in Liver Transplantation,” Surgery, 1992; 112(4): 704-11.
  4. Wang HL, Burgett FG, and Shyr Y: “The Relationship between Restoration and Furcation Involvement on Molar Teeth,” Journal of Periodontology, 1993; 64(4): 302-5.
  5. Wang HL, Yeh CT, Smith F, Burgett FG, Richards P, Shyr Y, and O’Neal R: “Evaluation of Ferric Oxalate as an Agent for Use During Surgery to Prevent Postoperative Root Hypersensitivity,” Journal of Periodontology, 1993; 64(11): 1040-4.
  6. Wang HL, Burgett FG, Shyr Y, and Ramfjord S: “The Influence of Molar Furcation Involvement and Mobility on Future Clinical Periodontal Attachment Loss,” Journal of Periodontology, 1994; 65(1): 25-9.
  7. Wang HL, Yuan K, Burgett F, Shyr Y, and Syed S: “Adherence of Oral Microorganisms to Guided Tissue Membrane: An In-Vitro Study,” Journal of Periodontology, 1994; 65(3): 211-8.
  8. Young PC, Shyr Y, and Schork MA: “The Role of the Primary-Care Physician in the Care of Children with Serious Hear Disease,” Pediatrics, 1994; 94(3): 284-90.
  9. Wang HL, Pappert TD, Castelli WA, Chiego DJ, Shyr Y, and Smith BA: “The Effect of Platelet-Derived Growth-Factor on the Cellular-Response on the Periodontium: An Autoradiographic Study on Dogs,” Journal of Periodontology, 1994; 65(5):429-36.
  10. Wang HL, O’Neal RB, Thomas CL, Shyr Y, and Macneil RL: “Evaluation of an Absorbable Collagen Membrane in Treating Class-II Furcation Defects,” Journal of Periodontology, 1994; 65: 1029-36.
  11. Loder RT, Farley FA, Herring JA, Schork MA, and Shyr Y: “Bone Age Determination in Children with Legg-Calve-Perthes Disease: A Comparison of Two Methods,” Journal of Pediatric Orthopedics, 1995; 15(1): 90-4.
  12. Calkins H, Shyr Y, Frumin H, Schork A, and Morady F: “The Value of the Clinical History in the Differentiation of Syncope due to Ventricular-Tachycardia, Atrioventricular-Block, and Neurocardiogenic Syncope,” American Journal of Medicine, 1995; 98(4): 365-73.
  13. Vrlenich LA, Bozynski MEA, Shyr Y, Schork MA, Roloff DW, and McCormick? MC: “The Effect of Bronchopulmonary Dysplasia on Growth at School Age,” Pediatrics, 1995; 95(6): 855-9.
  14. Chen CC, Wang HL, Glickman G, Shyr Y, and O’Neal R: “GTE Procedures Using Collagen Membrane With and Without Bone Grafts,” Journal of Dental Research, 1995; 74:592.
  15. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, and Roberts LJ: “Increase in Circulating Products of Lipid Peroxidation (F2-Isoprostanes) in Smokers. Smoking as a Cause of Oxidative Damage,” New England Journal of Medicine, 1995; 332(18): 1198-1203.
  16. Loder RT, Urquhart A, Steen H, Graziano G, Hensinger RN, Schlesinger A, Schork MA, and Shyr Y: “Variability in Cobb Angle Measurements in Children with Congenital Scoliosis,” British Journal of Bone and Joint Surgery, 1995; 77(5): 768-70.
  17. Herman GE, Schork MA, Shyr Y, Elfont EA, and Arbit S: “Histologists, Microtomy, Chronic Repetitive Trauma, and Techniques to Avoid Injury: I. A Statistical Evaluation of the Job Functions Performed by Histologists,” The Journal of Histotechnology, 1995; 18(2): 139-43.
  18. Norris AE, Ford K, Shyr Y, and Schork MA: “Heterosexual Experiences and Partnerships of Urban, Low-Income African-American and Hispanic Youth,” Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1996; 11(3): 288-300.
  19. Malicky DM, Soslowsky LJ, Blasier RB, and Shyr Y: “Anterior Glenohumeral Stabilization Factors: Progressive Effects in a Biomechanical Model,” Journal of Orthopedic Research, 1996; 14(2): 282-8.
  20. Darbar D, Davidson NC, Gillespie N, Choy AJ, Lang CC, Shyr Y, McNeill? GP, Pringle TW, and Struthers AD: “Diagnostic Value of B-Type Natriuretic Peptide Concentrations in Patients with Acute Myocardial Infarction,” American Journal of Cardiology, 1996; 78(3): 284-7.
  21. Johnson DH, Paul DM, Hande KR, Shyr Y, Blanke C, Murphy B, Lewis M, and DeVore? RF: “Placlitaxel Plus Carboplatin in Advanced Non-Small-Cell Lung Cancer: A Phase II Trial,” Journal of Clinical Oncology, 1996; 14(7): 2054-60.
  22. Zic JA, Stricklin GP, Greer JP, Kinney MC, Shyr Y, Wilson DC, and King LE: “Long-term Follow-up of Patients with Cutaneous T-cell Lymphoma Treated with Extracorporeal Photochemotherapy,” Journal of the American Academy of Dermatology, 1996; 35(6): 935-45.
  23. Chomsky DB, Lang CC, Rayos GH, Shyr Y, Yeoh TK, Pierson RN, Davis SF, and Wilson JR: “Hemodynamic Exercise Testing: A Valuable Tool in the Selection of Cardiac Transplantation Candidates,” Circulation, 1996; 94(2): 3176-83.
  24. Calkins H, Bahu M, Shyr Y, Schork A, Bolling S, Kou W, Kirsch M, and Morady F: “Relationship of Amiodarone to Postoperative Complications of Transthoracic Implantation of Automatic Implantable Cardioverter Defibrillators,” Panminerva Medica, 1996; 38(2): 89-97.
  25. Shyr Y and Kshirsagar AM: “Stepwise Canonical Analysis in Categorical Data,” Communications In Statistics: Theory and Methods, 1997; 26(7): 1575-83.
  26. Blanke C, DeVore? R, Shyr Y, Epstein B, Murray M, Hande K, Stewart S, and Johnson D: “A Pilot Study of Protracted Low-Dose Cisplatin and Etopside with Concurrent Thoracic Radiotherapy in Unresectable Stage III Non-small-cell Lung Cancer,” International Journal of Radiation Oncology Biology Physics, 1997; 37(1): 111-6.
  27. Wang HL, MacNeil? RL, Thomas C, and Shyr Y: “The Effect of an Absorbable Collagen Membrane on the Subgingival Microflora,” Journal of Peridontal Clinical Investigations, 1997; 9: 27-35.
  28. Kemp WE, Kerins DM, Shyr Y, and Byrd BF: “Optimal Albunex Dosing for Enhancement of Doppler Tricuspid Regurgitation Spectra,” American Journal of Cardiology, 1997; 79(2): 232-4.
  29. Coomer RW, Schulman G, Breyer JA, and Shyr Y: “Ambulatory Blood Pressure Monitoring in Hemodialysis and Peritoneal Dialysis Patients and Estimation of Mean Interdialytic Blood Pressure,” American Journal of Kidney Diseases, 1997; 29(5): 678-84.
  30. Metts JC, Kotkin L, Kasper S, Shyr Y, Adams MC, and Brock JW: “Genital Malformations and Coexistent Urinary Tract or Spinal Anomalies in Patients with Imperforate Anus,” Journal of Urology, 1997; 158(3): 1298-1300.
  31. Venkov CD, Su M, Shyr Y, and Vaughan DE: “Ethanol-Induced Alterations in the Expression of Endothelial-Derived Fibrinolytic Components,” Fibrinolysis & Proteolysis, 1997; 11(2): 115-8.
  32. Shyr Y and Kshirsagar AM: “A Formula for a Missing Plot in a General Incomplete Block Design, When Recovery of Interblock Information is Used,” Communications in Statistics: Theory and Methods, 1997; 26(12): 2855-60.
  33. Goral S, Ynares C, Shyr Y, Yeoh TK, and Johnson HK: “Long-term Renal Function in Heart Transplant Recipients Receiving Cyclosporine Therapy,” Journal of Heart and Lung Transplantation, 1997; 16(11): 1106-12.
  34. May RE, Himmelfarb J, Yenicesu M, Knights S, Ikizler TA, Schulman G, Hernanz-Schulman M, Shyr Y, and Hakim RM: “Predictive Measures of Vascular Access Thrombosis: A Prospective Study,” Kidney International, 1997; 52(6): 1656-62.
  35. Chinery R, Brockman JA, Peeler MO, Shyr Y, Beauchamp RD, and Coffey RJ: “Antioxidants Enhance the Cytotoxicity of Chemotherapeutic Agents in Colorectal Cancer: A P53-independent Induction of P21WAF1/CIP1 via C/Ebp Beta,” Nature Medicine, 1997; 3(11): 1233-41.
  36. Choy H, DeVore? RF, Hande KR, Porter LL, Rosenblatt P, Yunus F, Schlabach L, Smith C, Shyr Y, LaPorte? K, and Johnson DH: “Preliminary Analysis of a Phase II Study of Paclitaxel, Carboplatin, and Hyperfractionated Radiation Therapy for Locally Advance Inoperable Non-small Cell Lung Cancer,” Seminars in Oncology, 1997; 24(4): 21-6.
  37. Nicholson B, Paul D, Shyr Y, Garrett M, Hande KR, and Johnson DH: “Paclitaxel/5-Fluorouracil/Leucovorin in Metastatic Breast Cancer: a Vanderbilt Cancer Center Phase II Trial,” Seminars in Oncology, 1997; 24(4): 20-3.
  38. Shyr Y: “A Canonical Form of Anderson’s Classification Statistic,” Communications in Statistics: Theory and Methods, 1998; 27(3): 577-87.
  39. Chinery R, Beauchamp RD, Shyr Y, Kirkland SC, Coffey RJ, and Morrow JD: “Antioxidants Reduce Cyclooxygenase-2 Expression, Prostaglandin Production, and Proliferation in Colorectal Cancer Cells,” Cancer Research, 1998; 58(11): 2323-7.
  40. Shyr Y: “Applying Understanding and Not Misusing Medical Biostatistics,” Medical Newsletter of Chang Gung Memorial Hospital (Taiwan), 1998; 8: 24-5.
  41. Wolinsky PR, Banit D, Parker RE, Shyr Y, Snapper JR, Rutherford EJ, and Johnson KD: “Reamed Intramedullary Femoral Nailing After Induction of an “ARDS-like” State in Sheep: Effect on Clinically Applicable Markers of Pulmonary Function,” Journal of Orthopedic Trauma, 1998; 12(3): 169-75.
  42. Cowen ME, Dusseau DJ, Toth BG, Guisinger C, Zodet M, and Shyr Y: “Case-mix Adjustment of Managed Care Claims Data Using Clinical Classification for Health Policy Research Method,” Medical Care, 1998; 36(7): 1108-13.
  43. Shyr Y: “Applied Biostatistical Method and Models for Survival Analysis,” Medical Newsletter of Chang Gung Memorial Hospital (Taiwan), 1998; 8: 24-7.
  44. Wolinsky PR, McCarty EC, Shyr Y, and Johnson KD: “Length of Operative Procedures: Reamed Femoral Intramedullary Nailing Performed With and Without a Fracture Table,” Journal of Orthopedic Trauma, 1998; 12(7): 485-95.
  45. Fitzpatrick JM, Hill DLG, Shyr Y, West J, Studholme C, and Maurer CR: “Visual Assessment of the Accuracy of Retrospective Registration of MR and CT Images of the Brain,” IEEE Transactions on Medical Imaging, 1998; 17(4): 571-85.
  46. Evanson JA, Himmelfarb J, Wingard R, Knights S, Shyr Y, Schulman G, Ikizler TA, and Hakim RM: “Prescribed Versus Delivered Dialysis in Acute Renal Failure Patients,” American Journal of Kidney Diseases, 1998; 32(5): 731-8.
  47. Neyra NR, Ikizler TA, May RE, Himmelfarb J, Schulman G, Shyr Y, and Hakim RM: “Change in Access Blood Flow Over Time Predicts Vascular Access Thrombosis,” Kidney International, 1998; 54(5): 1714-9.
  48. Washington K, Chiappori A, Hamilton K, Shyr Y, Blanke C, Johnson D, Sawyers J, and Beauchamp D: “Expression of beta-catenin alpha-catkin, and E-cadherin in Barrett’s Esophagus and Esophageal Adenocarcinomas,” Modern Pathology, 1998; 11(9): 805-13.
  49. Lamps LW, Pinson CW, Raiford DS, Shyr Y, Scott MA, and Washington MK: “The Significance of Microabscesses in Liver Transplant Biopsies: A Clinicopathological Study,” Hepatology, 1998; 28(6): 1532-7.
  50. Shyr Y: “The Limitations and Extensions of Cox Model,” Medical Newsletter of Chang Gung Memorial Hospital (Taiwan), 1998; 8: 26-8.
  51. Ong MMA, Eber RM, Korsnes MI, MacNeil? RL, Glickman GN, Shyr Y, and Wang HL: “Evaluation of a Bioactive Glass Alloplast in Treating Periodontal Intrabony Defects,” Journal of Periodontology, 1998; 69(12): 1346-54.
  52. Hughes CA, O’Gorman LA, Shyr Y, Schlork MA, Bozynski MEA, and McCormick? MC: “Cognitive Performance at School Age of Very Low Birth Weight Infants with Bronchopulmonary Dysplasia,” Journal of Developmental and Behavioral Pediatrics, 1999; 20(1): 1-8.
  53. Norgaard P, Law B, Joseph H, Page DL, Shyr Y, Mays D, Pietenpol JA, Kohl NE, Oliff A, Coffey RJ, Poulsen HS, and Moses HL: “Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) Alpha and TGF alph/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis,” Clinical Cancer Research,1999; 5: 35-42.
  54. Chang AC, Shyr Y, Groves J, Chomsky DB, Davis SF, Wilson JR, Drinkwater DC, Pierson RN, and Merrill WH: “The Utility of Exercise Testing After Cardiac Transplantation in Older Patients,” Journal of Surgical Research, 1999; 81(1): 48-54.
  55. Evanson JA, Ikizler TA, Wingard R, Knights S, Shyr Y, Schulman G, Himmelfarb J, and Hakim RM: “Measurement of the Delivery of Dialysis in Acute Renal Failure,” Kidney International, 1999; 55(4): 1501-8.
  56. Wolinsky PR, McCarty E, Shyr Y, and Johnson K: “Reamed Intramedullary Nailing of the Femur: 551 Cases,” Journal of Trauma – Injury Infection and Critical Care, 1999; 46(3): 392-9.
  57. Choy H, LaPorte? K, Knill-Selby E, Mohr P, and Shyr Y: “Esophagitis in Combined Modality Therapy for Locally Advanced Non-small Cell Lung Cancer,” Seminars in Radiation Oncology, 1999; 9(2): 90-6.
  58. Ikizler TA, Wingard RL, Harvell J, Shyr Y, and Hakim RM: “Association of Morbidity with Markers of Nutrition and Inflammation in Chronic Hemodialysis Patients: A Prospective Study,” Kidney International, 1999; 55(5): 1945-51.
  59. Cmelak A, Choy H, Shyr Y, Mohr P, Glantz MJ, and Johnson DH: “National Survey on Prophylactic Cranial Irradiation: Difference in Practice Patterns Between medical and Radiation Oncologists,” International Journal of Radiation Oncology, Biology, & Physics, 1999; 44(1): 157-62.
  60. Shyr Y: “Statistical Strategies for Modeling the Quasi-Sinusoidality of Time-Qualified Data,” Statistical Modeling, 1999; 14: 664-8.
  61. Hohenfellner K, Hunley TE, Brezinska R, Brodhag P, Shyr Y, Brenner W, Habermehl P, and Kon V: “ACE I/D Gene Polymorphism Predicts Renal Damage in Congenital Uropathies,” Pediatric Nephrology, 1999; 13(6): 514-8.
  62. Holcomb GW, Morgan WM, Neblett WW, Pietsch JB, O’Neill JA, and Shyr Y: “Laparoscopic Cholecystectomy in Children: Lessons Learned From the First 100 Patients,” Journal of Pediatric Surgery, 1999; 34(8): 1236-40.
  63. Herline AJ, Pinson CW, Wright JK, Debelak JP, Shyr Y, Harley D, Merrill WH, Starkey T, Pierson R and Chapman WC: “Acute Pancreatitis After Cardiac Transplantation and Other Cardiac Procedures: Case-control Analysis in 24,631 Patients,” American Surgeon, 1999; 65(9) 819-25.
  64. Rehman SU, Pupim LB, Shyr Y, Hakim R, and Ikizler TA: “Intradialytic Serial Vascular Access Flow Measurements,” American Journal of Kidney Disease, 1999; 34(3): 471-7.
  65. Becker BN, Coomer RW, Fotiadis C, Evanson J, Shyr Y, and Hakim RM: “Risk Factors for Hospitalization in Well-Dialyzed Chronic Hemodialysis Patients,” American Journal of Nephrology, 1999; 19(5): 565-70.
  66. Delbeke D, Rose DM, Chapman WC, Pinson CW, Wright JK, Beauchamp RD, Shyr Y, and Leach SD: “Optimal of FDG PET in the Diagnosis, Staging and Management of Pancreatic Carcinoma,” Journal of Nuclear Medicine, 1999; 40(11): 1784-91.
  67. Lowe LH, Banks WJ, and Shyr Y: “Pyloric Ratio: Efficacy in the Diagnosis of Hypertrophic Pyloric Stenosis,” Journal of Ultrasound In Medicine, 1999; 18(11): 773-7.
  68. Zhang JP, Blum MG, Chang AC, Shyr Y, Blair KSA, Awad M, and Pierson RN: “Immunohistologic Evaluation of Mechanisms Mediating Hyperacute Lung Rejection, and the Effect of Treatment with K76-COOH, FUT-175 and Anti-Gal Column Immune Absorption,” Xenotransplantation, 1999; 6(4): 249-61.
  69. Franke JJ, Gilbert WB, Grier J, Koch MO, Shyr Y, and Smith JA: “Early Post-Prostatectomy Pelvic Floor Biofeedback,” Journal of Urology, 2000; 163(1): 191-3.
  70. Choy H, Shyr Y, Cmelak AJ, Mohr PJ, and Johnson DH: “Patterns of Practice Survey for Non-small Cell Lung Carcinoma in the U.S.,” Cancer, 2000; 88(6): 1336-46.
  71. Roberts JR, Shyr Y, Christian KR, Drinkwater D, and Merrill W: “Preemptive Gastrointestinal Tract Management Reduces Aspiration and Respiratory failure After Thoracic Operations,” Journal of Thoracic and Cardiovascular Surgery, 2000; 199(3): 449-52.
  72. Mertz H, Morgan V, Tanner G, Pickens D, Price R, Shyr Y, and Kessler R: “Regional Cerebral Activation In Irritable Bowel Syndrome and Control Subjects with Painful and Nonpainful Rectal Distention,” Gastroenterology, 2000; 118(5): 842-8.
  73. Chakravarthy A, Nicholson B, Kelley M, Beauchamp D, Johnson D, Frexes-Steed M, Simpson J, Shyr Y, and Pietenpol J: “A Pilot Study of Neoadjuvant Paclitaxel and Radiation with Correlative Molecular Studies in Stage II/III breast Cancer,” Clinical Breast Cancer, 2000; 1(1): 68-71.
  74. Choy H, DeVore? RF, Hande KR, Porter LL, Rosenblatt P, Yunus F, Schlabach L, Smith C, Shyr Y, and Johnson DH: “A Phase II Study of Paclitaxel, Carboplatin and Hyperfractionated Radiation Therapy for Locally Advanced Inoperable Non-small Cell Lung Cancer (a Vanderbilt Cancer Center Affiliate Network Study),” International Journal of Radiation Oncology, Biology, Physics, 2000; 1: 47(4): 931-7.
  75. Hernanz-Schulman Foster C, Maxa R, Battles G, Dutt P, Stratton C, Holburn G, Schulman G, Neblett WW, Shyr Y, Hakim RR, Vanholder R, and Heller RM: “Experimental Study of Mortality and Morbidity of contrast Media and Standardized Fecal Dose in the Peritoneal Cavity,” Pediatric Radiology, 2000: 30(6): 369-78.
  76. Nicholson BP, Paul DM, Hande KR, Shyr Y, Meshad M, Cohen A, and Johnson DH: “Paclitaxel, 5-Fluorouracil and Leucovorin (TFL) in the Treatment of Metastatic Breast Cancer,” Clinical Breast Cancer, 2000; 1(2): 136-43.
  77. Komhoff M, Guan YF, Shappell HW, Davis L, Jack G, Shyr Y, Koch MO, Shappell SB, and Breyer MD: “Enhanced Expression of Cyclooxgenase-2 in High Grade Human transitional Cell Bladder Carcinomas,” American Journal of Pathology, 2000; 157(1): 29-35.
  78. Washington K, Wright K, Shyr Y, Hunter EB, Olson S, and Raiford DS: “Hepatic Stellate Cell Activation in Nonalcoholic Steatohepatitis and Fatty Liver,” Human Pathology, 2000; 31(7): 822-8.
  79. Xu XC, Clarke P, Szalai G, Shively JE, Williams LE, Shyr Y, Shi EG, and Primus FJ: “Targeting and Therapy of Carcinoembryonic Antigen-Expressing Tumors in Transgenic Mice with an Antibody Interleutin-2 Fusion Protein,” Cancer Research, 2000; 60(16): 4475-84.
  80. Shyr Y: “The Statistical Strategies for Modeling the Relationship between Multiple Variable and RNA Expression Data and Clinical Endpoints,” Proceeding of Taiwan Biotechnology Symposiums, 2000: 1-14.
  81. Shyr Y: “The Current Challenges and Future of Bioinformatics,” Proceeding of Taiwan Biotechnology Symposiums, 2000; 15-22.
  82. Tingstad EM, Wolinsky PR, Shyr Y, and Johnson KD: “Effect of Immediate Weight-bearing on Plated Fractures of the Humeral Shaft,” Journal of Trauma – Injury Infection and Critical Care, 2000; 49(2): 278-80.
  83. Lowe LH, Penney MW, Scheker LE, Perez R, Stein SM, Heller RM, Shyr Y, and Hernanz-Schulman M: “Appendicolith Revealed on CT in Children With Suspected Appendicitis: How Specific is it in the Diagnosis of Appendicitis?” American Journal of Roentgenology, 2000; 175(4): 981-4.
  84. Mizobata S, Thompkins K, Simpson JF, Shyr Y, and Primus FJ: “Induction of Cytotoxic T Cells and Their Antitumor Activity in Mice Transgenic for Carcinoembryonic Antigen,” Cancer Immunology Immunotherapy, 2000; 49(6): 285-95.
  85. Neyra NR, Hakim RM, Shyr Y, and Ikizler TA: “Serum Transferrin and Serum Prealbumin are Early Predictors of Serum Albumin in Chronic Hemodialysis Patients,” Journal of Renal Nutrition, 2000; 10(4): 184-90.
  86. Stefansic JD, Herline AJ, Shyr Y, Chapman WC, Fitzpatrick JM, Dawant BM, and Galloway RL: “Registration of Physical Space to Laparoscopic Image Space for Use in Minimally Invasive Hepatic Surgery,” IEEE Transactions on Medical Imaging, 2000; 19(10): 1012-23.
  87. Lowe LH, Penney MW, Stein SM Heller RM, Neblett WW, Shyr Y, and Hernanz-Schulman M: “Unenhanced Limited CT of the Abdomen in the Diagnosis of Appendicitis in Children: Comparison with Sonography,” American Journal of Roentgenology, 2001; 176(1): 31-5.
  88. Washington K, Debelak JP, Gobbell C, Sztipanovits DR, Shyr Y, Olsen S, and Chapman WC: “Hepatic Cryoablation-Induced Acute Lung Injury: Histopathologic Findings,” The Journal of Surgical Research, 2001; 95(1): 1-7.
  89. Jagasia MH, Langer CJ, Johnson DH, Yunus F, Rodgers JS, Schalbach LL, Cohen AG, Shyr Y, Krozely P, McCullough? N, Carbone DP, and DeVore? RF: “Weekly Irinotecan and Cisplatin in Advanced Non-small Cell Lung Cancer: A Multicenter Phase II Study,” Clinical Cancer Research, 2001; 7(1): 68-73.
  90. Dowell JE, Johnson DH, Rogers JS, Shyr Y, McCullough? N, Krozely P, and DeVore? RF: “A Phase II Trial of 6-hydroxymethylacylfulvene (MGI0114, Irofulven) in Patients with Advanced Non-small Cell Lung Cancer Previously Treated with Chemotherapy,” Investigational New Drugs, 2001; 19(1): 85-8.
  91. Blanke CD, Stipanov M, Morrow J, Rothenberg M, Chinery R, Shyr Y, Coffey R, Johnson DH, Leach SD, and Beauchamp RD: “A Phase I Study of Vitamin E, 5-Fluorouracil and Leucovorin For Advanced Malignancies,” Investigational New Drugs, 2001; 19(1): 21-7.
  92. Dowell JE, Garrett AM, Shyr Y, Johnson DH, and Hande KR: “A Randomized Phase II Trial in Patient with Carcinoma of an Unknown Primary Site,” Cancer, 2001: 91(3): 592-7.
  93. Tham KT, Peek RM, Atherton JC, Cover TL, Perez-Perez GI, Shyr Y, and Blaser MJ: “Helicobacter Pylori Genotypes, Host Factors, and Gastric Mucosal Histopathology in Peptic Ulcer Disease,” Human Pathology, 2001; 32(3): 264-73.
  94. Sofowora GG, Choo EF, Mayo G, Shyr Y, and Wilkinson GR: “In Vivo Inhibition of Human CYP1A2 Activity By Oltipraz,” Cancer Chemotherapy and Pharmacology, 2001; 47(6): 505-10.
  95. Deane NG, Parker MA, Aramandla R, Diehl L, Lee WJ, Washington MK, Nanney LB, Shyr Y, and Beauchamp RD: “Hepatocellular Carcinoma Results From Chronic Cyclin D1 Overexpression in Transgenic Mice,” Cancer Research, 2001; 61(14): 5389-95.
  96. McCarty EC, Spindler KP, Tingstad E, Shyr Y, and Higgins M: “Does Intraarticular Morphine Improve Pain control with Femoral Nerve Block after Anterior Cruciate Ligament Reconstruction?” American Journal of Sports Medicine, 2001; 29(8): 327-32.
  97. Montgomery E, Bronner M, Goldblum J, Greenson J, Haber M, Hart J, Lamps L, Lauwers G, Lazenby A, Lewin D, Robert M, Toledano A, Shyr Y, and Washington K: “Diagnostic Reproducibility of the Diagnosis of Dysplasia in Barrett’s Esophagus: A Reaffirmation,” Human Pathology, 2001; 32(4): 368-78.
  98. Amorino GP, Lee H, Holburn GE, Paschal CB, Hercules SK, Shyr Y, Steffen RP, and Choy H: “Enhancement of Tumor Oxygenation and Radiation Response by the Allosteric Effector of Hemoglobin, rsr13,” Radiation Research, 2001; 156(3): 294-300.
  99. Murphy BA, Cmelak A, Burkey B, Netterville J, Shyr Y, Douglas S, and Smith W: “Topoisomerase I Inhibitors in the Treatment of Head and Neck Cancer,” Oncology, 2001: 15: 47-52.
  100. Saadeh E, Ikizler TA, Shyr Y, Hakim RM, and Himmelfarb J: “Recombinant Human Growth Hormone in Patients with Acute Renal Failure,” Journal of Renal Nutrition, 2001; 11(4): 212-9.
  101. Wang HL, Bunyaratavej P, Labadie M, Shyr Y, and MacNeil? RL: “Comparison of Two Clinical Techniques for Treatment of Gingival Recession,” Journal of Periodontology, 2001; 72: 1301-11.
  102. Pietrow P, Parekh DJ, Smith JA, Shyr Y, and Cookson M: “Health Related Quality of Life Effect Assessment after Radical Prostatectomy in Men with Prostate Specific Antigen Only Recurrence,” Journal of Urology, 2001; 166(6): 2286-90.
  103. McCarley? P, Wingard RL, Shyr Y, Pettus W, Hakim RM, and Ikizler TA: “Vascular Access Blood Flow Monitoring Reduces Access Morbidity and Costs,” Kidney International, 2001; 60(3): 1164-72.
  104. Choy H, DeVore? RF, Hande KR, Porter LL, Rosenblatt PA, Slovis B, LaPorte? K, Shyr Y, and Johnson DH: “Phase I Trial of Outpatient Weekly Docetaxel, Carboplatin and Concurrent Thoracic Radiation Therapy for Stage III Unresectable Non-small Cell Lung Cancer: a Vanderbilt Caner Center Affiliate Network (VCCAN) Trial,” Lung Cancer, 2001, 34(3):441-9.
  105. Chen S-Y, Wang H-L, Glickman GN, Shyr Y, and MacNeil? RL: “Multivariate Analysis of Factors Influencing Outcomes of Regenerative Therapy: A Retrospective Study,” International Chinese Journal of Dentistry, 2002; 2: 50-9.
  106. Wudel LJ, Wright JK, Debelak JP, Allos TM, Shyr Y, and Chapman WC: “Prevention of Gallstone Formation in Morbidly Obese Patients Undergoing Rapid Weight Loss: Results of a Randomized Controlled Pilot Study,” Journal of Surgical Research, 2002; 102(1): 50-6.
  107. Pietrow PK, Pope JC, Adams MC, Shyr Y, and Brock JW: “Clinical Outcome of Pediatric Stone Disease,” Journal of Urology, 2002; 167(2): 670-3.
  108. Himmelfarb J, Evanson J, Hakim RM, Freedman S, Shyr Y, and Ikizler TA: “Urea Volume of Distribution Exceeds Total Body Water in Patients with Acute Renal Failure,” Kidney International, 2002; 61(1): 317-23.
  109. Hallahan DE, Geng L, and Shyr Y: “Effects of Intercellular Adhesion Molecule-1 (ICAM-1) Null Mutation on Radiation-Induced Pulmonary Fibrosis and Respiratory Insufficiency in Mice,” Journal of the National Cancer Institute, 2002; 94(10): 733-41.
  110. Boyd AS, Shyr Y, and King LE Jr.: “Basal Cell Carcinoma in Young Women: an Evaluation of the Association of Tanning Bed Use and Smoking,” Journal of the American Academy of Dermatology, 2002; 46(5 Pt 1): 706-9.
  111. Wudel LJ Jr., Chapman WC, Shyr Y, Davidson M, Jeyakumar A, Rogers SO Jr., Allos T, and Stain SC: “Disparate Outcomes in Patients with Colorectal Cancer: Effect of Race on Long-term Survival,” Archives of Surgery, 2002; 137(5): 550-6.
  112. Pupim LB, Kent P, Caglar K, Shyr Y, Hakim RM, and Ikizler TA: “Improvement in Nutritional Parameters After Initiation of Chronic Hemodialysis,” American Journal of Kidney Disorders, 2002; 40(1): 143-51.
  113. Miller MF, McDowell? T, Small SE, Shyr Y, and Kemp NR: “Hardly Used Habitats: Dearth and Distribution of Burrowing in Paleozoic and Mesozoic Stream and Lake Deposits,” Geology, 2002; 30(6): 527-30.
  114. Caglar K, Fedje L, Dimmitt R, Hakim RM, Shyr Y, and Ikizler TA: “Therapeutic Effects of Oral Nutritional Supplementation During Hemodialysis, “Kidney International, 2002; 62(3):1054-9.
  115. Ikizler TA, Morrow JD, Roberts LJ, Evanson JA, Becker B, Hakim RM, Shyr Y, and Himmelfarb J: “Plasma F2-Isoprostane Levels are Elevated in Chronic Hemodialysis Patients,” Clinical Nephrology, 2002; 58(3):190-7.
  116. Washington K, Greenson J, Montgomery E, Shyr Y, Crissinger K, Polk B, Barnard J, and Lauwers G: “Histopathology of Ulcerative Colitis in Initial Rectal Biopsy in Children,” American Journal of Surgical Pathology, 2002; 26 (11): 1441-9.
  117. Neyra R, Chen KY, Sun M, Shyr Y, Hakim RM, and Ikizler TA: “Increased Resting Energy Expenditure in Patients With End-Stage Renal Disease,” Journal of Parenteral and Enteral Nutrition, 2003; 27(1): 36-42.
  118. Yang L, Yamagata N, Yadav R, Brandon S, Coutney R, Shyr Y, Boothby M, Joyce S, Breyer R, and Carbone D: “Cancer-associated Immunodeficiency and Dendritic Cell Abnormalities Mediated by the Prostaglandin Receptor EP2,” Journal of Clinical Investigation, 2003; 111(5): 727-35.
  119. Shyr Y: “Statistical Strategies for Analyzing the Microarray Data in Human Lung Cancer” Lung Cancer, 2003; 41(2003): 90-1.
  120. Wudel LJ Jr, Delbeke D, Morris D, Rice M, Washington MK, Shyr Y, Pinson CW, and Chapman WC: “The Role of [18F]fluorodeoxyglucose Positron Emission Tomography Imaging in the Evaluation of Hepatocellular Carcinoma,” American Surgery, 2003; 69(2): 117-26.
  121. Yanagisawa K, Shyr Y, Xu BJ, Massion PP, Larsen PH, Whit BC, Roberts JR, Gonzalez A Nadaf S, Moore JH, Caprioli RM, Carbone, DP: “Tumor Proteomic Patterns Predict Classification and Tumor Behavior in Human Non-small Cell Lung Cancer,” Lancet, 2003; 362(9382): 433-9.
  122. Tu WH, Thomas TZ, Masumori N, Bhowmick NA, Gorska AE, Shyr Y, Kasper S, Case T, Roberts RL, Shappell SB, Moses HL, and Matusik RJ: “The Loss of TGF-beta Signaling Promotes Prostate Cancer Metastasis,” Neoplasia, 2003; 5(3): 267-77.
  123. Xie L, Law B, Aakre M, Edgerton M, Shyr Y, Bhowmick N, and Moses H: “TGFβ Regulated Gene Expression in a Mouse Mammary Gland Epithelial Cell Line,” Breast Cancer Research, 2003, 5: 187-98.
  124. Yamagata N, Shyr Y, Yanagisawa K, Edgerton M, Dang TP, Gonzalez A, Nadaf S, Larsen P, Roberts JR, Nesbitt JC, Jensen R, Levy S, Moore JH, Minna JD, and Carbone DP.: “A Training-Test Approach to the Molecular Classification of Resected Non-Small Cell Lung Cancer,” Clinical Cancer Research, 2003; 9(13): 4695-4704.
  125. Massion PP, Taflan PM, Jamshedur Rahman SM, Yildiz P, Shyr Y, Edgerton ME, Westfall MD, Roberts JR, Pietenpol JA, Carbone DP, and Gonzalez AL: “Significance of P63 Amplification and Overexpression in Lung Cancer Development and Prognosis” Cancer Research, 2003; 63(21): 7113-21.
  126. Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, and Moses HL: “Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-Beta Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation,” American Journal of Pathology, 2003; 163(4): 1539-49.
  127. VanderVeen? LA, Hashim MF, Shyr Y, and Marnett LJ: “Induction of Frameshift and Base Pair Substitution Mutations by the Major DNA Adduct of the Endogenous Carcinogen, Malondialdehyde,” Proc Natl Acad Sci USA, 2003; 100(24): 14247-52.
  128. Kim JC, Kim JS, Saha D, Cao Q, Shyr Y, and Choy H: "Potential Radiation Sensitizing Effect of Semisynthetic Epothilone B in Human Lung Cancer Cells," Radiother Oncol, 2003; 68(3): 305-13.
  129. Ikizler TA, Sezer MT, Flakoll PJ, Hariachar S, Kanagasundaram NS, Gritter N, Knights S, Shyr Y, Paganini E, Hakim RM, and Himmelfarb J: “Urea Space and Total Body Water Measurements by Stable Isotopes in Patients with Acute Renal Failure,” Kidney International, 2004; 65(2): 725-32.
  130. Tedesco KL, Thor AD, Johnson DH, Shyr Y, Blum KA, Goldstein LJ, Gradishar WJ, Nicholson BP, Merkel DE, Murrey D, Edgerton S, and Sledge GW Jr.: “Docetaxel Combined with Trastuzumab Is an Active Regimen in HER-2 3+ Overexpressing and Fluorescent In Situ Hybridization-Positive Metastatic Breast Cancer: a Multi-Institutional Phase II Trial,” Journal of Clinical Oncology, 2004; 22(6): 1071-7.
  131. Jennings MT, Cmelak A, Helton KJ, Johnson MD, Moots P, Pais R, and Shyr Y: “Differential Responsiveness among “High Risk” Pediatric Brain Tumors in a Pilot Study of Dose-Intensive Induction Chemotherapy,” Pediatric Blood Cancer, 2004; 43(1): 46-54.
  132. Pupim LB, Himmelfarb J, McMonagle? E, Shyr Y, and Ikizler AT: “Influence of Initiation of Maintenance Hemodialysis on Biomarkers of Inflammation and Oxidative Stress,” Kidney International, 2004; 65(6): 2371-9.
  133. Simmons EM, Himmelfarb J, Sezer MT, Chertow GM, Mehta RL, Paganin EP, Soroko S, Freedman S, Becker K, Spratt D,, Shyr Y, and Ikizler TA: “Plasma Cytokine Levels Predict Mortality in Patients with Acute Renal Failure,” Kidney International, 2004; 65(4): 1357-65.
  134. Kimble KM, Eber RM, Soehren S, Shyr Y, Wang HL: “Treatment of Gingival Recession Using a Collagen Membrane with or without the use of Demineralized Freeze-Dried Bone Allograft for Space Maintenance,” Journal of Periodontology, 2004; 75(2): 210-20.
  135. Gonzalez AL, Roberts RL, Massion PP, Olson SJ, Shyr Y, and Shappell SB: “15-Lipoxygenase-2 Expression in and Neoplastic Lung: An Immunohistochemical Study and Correlation with Tumor Grade and Proliferation,” Human Pathology, 2004; 35(7): 840-49.
  136. Jagasia M, Morgan D, Goodman S, Hamilton K, Kinney M, Shyr Y, Stein R, Zic J, Greer J: "Histology Impacts the Outcome of Peripheral T-cell Lymphomas after High Dose Chemotherapy and Stem Cell Transplant," Leukemia & Lymphoma, 2004; 45(11): 2261-67.
  137. Pupim LB, Caglar K, Hakim RM, Shyr Y, Ikizler TA: "Uremic Malnutrition is a Predictor of Death Independent of Inflammatory status," Kidney International, 2004; 66(5): 2054-60.
  138. Lu B, Gonzalez A, Massion PP, Shyr Y, Shaktour B, Carbone DP, Hallahan DE: "Nuclear Survivin as a Biomarker for Non-Small-Cell Lung Cancer," British Journal of Cancer, 2004; 91(3): 537-40.
  139. Yang L, DeBusk? LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DO, Lin PC: "Expansion of Myeloid Immune Suppressor Gr=CD11b+cells in Tumor-Bearing Host Directly Promotes Tumor Angiogenesis," Cancer Cell, 2004; 64: 409-21.
  140. Massion PP, Taflan PM, Shyr Y, Rahman SM, Yildiz P, Shakthour B, Edgerton ME, Ninan M, Andersen JJ, Gonzalez AL: "Early Involvement of the Phosphatidylinositol 3-kinase/Akt pathway in Lung Cancer Progression," American Journal Respir Crit Care Med, 2004; 6(4): 4094-21.
  141. Osusky KL, Hallahan DE, Fu A, Ye F, Shyr Y, Geng L: “The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels,” Angiogenesis, 2004; 7: 225-33.
  142. Yi Y, Mirosevich J, Shyr Y, Matusik R, George A Jr.: "Coupled analysis of gene expression and chromosomal location," Genomics, 2005; 85: 401-12.
  143. Park YK, Franklin JL, Settle SH, Levy SE, Chung E, Jeyakumar LH, Shyr Y, Washington MK, Whitehead RH, Aronow BJ, Coffey RJ: "Gene Expression Profile Analysis of Mouse Colon Embryonic Development," Genesis, 2005; 41(1): 1-12.
  144. Kuhn JE, Huston LJ, Soslowsky LJ, Shyr Y, Blasier RB: “External Rotation of the Glenohumeral Joint: Ligament Restraints and Muscle Effects in the Neutral and Abducted Positions,” J Shoulder Elbow Surg, 2005; 14(1 Suppl S): 39S-48S.
  145. Tedesco Kl, Berlin J, Blanke CD, Teng M, Choy H, Roberts J, Beauchamp RD, Leach S, Wyman K, Tarpley J, Shyr Y, Caillouette C, Chakravarthy B: "Phase I Trial of Orzel (UFT plus leucovorin), Cisplatin, and Radiotherapy in the Treatment of Potentially Respectable Esophageal Cancer," Int. J. Radiat Oncol Biol Phys, 2005; 1;61(5): 1364-70.
  146. Shinohara ET, Geng L, Tan J, Chen H, Shyr Y, Edwards E, Halbrook J, Kesicki EA, Kashishian A, Hallahan DE: "DNA-dependent Protein Kinase is a Molecular Target for the Development of Noncytotoxic Radiation Sensitizing Drugs," Cancer Res, 2005; 65(12): 4987-92.
  147. Boyd AS, Wu H, Shyr Y: “Monster Cells in Malignant Melanoma,” Am J Dermatopathol, 2005; 27(3): 208-10.
  148. Shinohara ET, Gonzalez A, Massion PP, Chen H, Li M, Freyer As, Olson SJ, Andersen JJ, Shyr Y, Carbone DP, Johnson DH, Hallahan DE, Lu B, "Nuclear Surviving Predicts Recurrence and Poor Survival in Patients with Resected Nonsmall Cell Lung Carcinoma," Cancer Res, 2005; 103(8):1685-92.
  149. Maas K, Chen H, Shyr Y, Olsen NJ, Aune T: "Shared Gene Expression Profiles in Individuals with Autoimmune Disease and Unaffected First-degree Relatives of Individuals with Autoimmune Disease," Hum Mol Gene, 2005; 14(10): 1305-14.
  150. Basi S, Pupim LB, Simmons EM, Sezer MT, Shyr Y, Freedman S, Chertow GM, Mehta RL, Paganini E, Himmelfarb J, Ikizler TA, "Insulin resistance in critically ill patients with acute renal failure,” AM J Physiol Renal Physiol, 2005; 289(2): F259-64.
  151. Tedesco KL, Berlin J, Rothenberg M, Choy H, Wyman K, Scott Pearson A, Daniel Beauchamp R, Merchant N, Craig Lockhart A, Shyr Y, Caillouette C, Chakravarthy B, "A Phase I Study of Concurrent 9-nitro-20(s)-Camptothecin (9NC/Orathecin) and Radiation Therapy in the Treatment of Locally Advanced Adenocarcinoma of the Pancreas," Radiother Oncol, 2005; 76(1):54-8.
  152. Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Bradt SJ, Roberts J, Zhang X, Shyr Y, Kinney MC, "Differential Gene Expression in Anaplastic Lymphoma Kinase-Positive and Anaplastic Lymphoma Kinase-Negative Anaplastic Large Cell Lymphomas," Hum Pathol, 2005; 36(5): 494-504.
  153. Grau AM, Ata A, Foster L, Ahmed Nu, Gorman Dr, Shyr Y, Stain SC, Pearson AS, "Effect of Race on Long-term Survival of Breast Cancer Patients: Transinstitutional Analysis from an Inner City Hospital and University Medical Center," Am Surg, 2005; 71(2):164-70.
  154. Xu BJ, Shyr Y, Liang X, Ma LJ, Donner EM, Roberts JD, Zhang X, Kon V, Brown NJ, Caprioli RM, Fogo AB, "Proteomic Patterns and Prediction of Glomerulosclerosis and Its Mechanisms," J Am Soc Nephrol, 2005; 16(10): 2967-75.
  155. Csiki I, Morrow JD, Sandler A, Shyr Y, Oates J, Williams MK, Dang T, Carbone DP, Johnson DH, "Targeting Cyclooxygenase-2 in Recurrent Non-small Cell Lung Cancer: A Phase II Trial of Celecoxib and Ocetaxel." Clinical Cancer Research, 2005; 11 (18):6634-40.
  156. Schwartz SA, Weil RJ, Thompson RC, Shyr Y, Moore JH, Toms SA, Johnson MD, Caprioli RM, "Proteomic-Based Prognosis of Brain Tumor Patients Using Direct-Tissue Matrix-Assisted Laser Desorption Ionization Mass Spectrometry,” Cancer Research, 2005; 65(17):7674-81.
  157. Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, Baldwin HS, Johnson JE, de Caestecker MP, "Bone Morphogenetic Protein 4 Promotes Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension," Circulation Research, 2005; 97(5):496-504.
  158. Kim Dw, Shyr Y, Shaktour B, Akerley W, Johnson DH, Choy H, "Long-term Follow-up and Analysis of Long-term Survivors in Patients Treated with Paclitaxel-based Concurrent Chemo-radiation Therapy for Locally Advanced Non-small Cell Lung Cancer," Lung Cancer, 2005; 50(2): 235-45.
  159. Bui C, Chen H, Shyr Y, Joos K, "Discontinuing Nasal Steroids May Lower Intraocular Pressure in Glaucoma," J Allergy Clin Immun, 2005; 116(5):1042-7.
  160. Brantley-Sieders DM, Fang WB, Hicks DJ, Zhuang G, Shyr Y, Chen J: Impaired Tumor Microenvironment in EphA2?-Deficient Mice Inhibits Tumor Angiogenesis and Metastatic Progression,” JASEB J, 2005; 19(13):1884-6.
  161. Rahman SM, Shyr Y, Yildiz PB, Gonzalez AL, Li H, Zhang X, Chaurand P, Yanagisawa K, Slovis BS, Miller RF, Ninan M, Miller YE, Franklin WA, Caprioli RM, Carbone DP, Massion PP: “Proteomic Patterns of Preinvasive Bronchial Lesions,” Am J Respir Crit Care Med, 2005; 172(12):1556-62.
  162. Xie L, Xu BJ, Gorska AE, Shyr Y, Schwartz SA, Cheng N, Levy S, Bierie B, Caprioli RM, Moses HL, “Genomic and Protenomic Analysis of Mammary Tumors Arising in Transgenic Mice,” Journal of Proteome Research, 2005; 4(6):2088-98.
  163. Kim DW, Shyr Y, Chen H, Akerley W, Johnson DH, Choy H, "Response to Combined Modality Therapy Correlates with Survival in Locally Advanced Non-small-cell Lung Cancer," Int J Radiat Oncol Biol Phys, 2005; 5:1042-7.
  164. Geng L, Shinohara ET, Kim D, Tan J, Osusky K, Shyr Y, Hallahan DE: STI5711 (Gleevec) Improves Tumor Growth Delay and Survival in Irradiated Mouse Models of Glioblastoma,” Int J Radiat Oncol Biol Phys, 2006; 64(1):263-71.
  165. Wright RW, Boyce RH, Michener T, Shyr Y, McCarty ED, Spindler KP: “Radiographs Are Not useful in Detecting Arthroscopically Confirmed Mild Chondral Damage,” Clin Orthop Relat Res, 2006; 442:245-51.
  166. Dennehy MK, Richards KA, Wernke GR, Shyr Y, Liebler DC: “Cytosolic and Nuclear Protein Targets of Thiol-reactive Electrophiles,” 2006; 19(1):20-9.
  167. Baker SG, Barnett SK, McIntosh? M, Patterson BH, Shyr Y, Skates S: “Evaluating Markers for the Early Detection of Cancer: Overview of Study Designs and Methods,” Clinical Trials, 2006; 3(1): 43-56.
  168. Wetzel JD, Barton ES, Chappell JD, Baer GS, Mochow-Grundy M, Rodgers SE, Shyr Y: Powers AC, Thomas JW, Dermody TS, “Reovirus Delays Diabetes Onset But Does Not Prevent Insulitis in Nonobese Diabetic Mice,” J Virol, 2006; 80(6):3078-82.
  169. Slebos R, Yi Y, Ely K, Carter J, Evjen A, Zhang X, Shyr Y, Murphy B, Cmelak A, Burkey B, Netterville J, Levy S, Yarbrough W, Chung C, "Gene Expression Difference Associated with HPV Status in Head and Neck Squamous Cell Carcinoma," Clinical Cancer Research, 2006; 12(3 Pt 1):701-9.
  170. Cuneo KC, Geng L, Tan J, Brousal J, Sinohara ET, Osusky K, Fu A, Shyr Y, Wu H, Hallahan DE, “SRC Family Kinase Inhibitor SU6656 Enhances Antiangiogenic Effect of Irradiation,” Int J Radiat Oncol Biol Phys, 2006; 64(4):1197-1203.
  171. Hong D, Shyr Y: “Wavelets in Biostatistics,” Journal of Concrete and Applicable Mathematics, 2006; (4):505-21.
  172. Slebos RCJ, Li M, Evjen AN, Coffa J, Shyr Y, Yarbrough WG: “Mutagenic Effect of Cadmium on Tetranucleotide Repeats in Human Cells,” Mutation Research, 2006; 602(1-2):92-9.
  173. Shames DS, Girard L, Gao B,, Sato M, Lewis CM, Shivapurkar N, Jiang A, Perou CM, Kim YH, Pollack JR, Fong KM, Lam CL, Wong M, Shyr Y, et al. : “A Genome-Wide screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies,” PLoS? Medicine, 2006; 3(12):e486.
  174. Kim DW, Blanke CD, Wu H, Shyr Y, Berlin J, Beauchamp RD, Chakravarthy B:” Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer,” Int J Radiat Oncol Biol Phy, 2007; 67(2):397-404.
  175. Wall RJ, Shyr Y, Smalley W: “Nonsteroidal Anti-Inflammatory Drugs and Lung Cancer Risk: A Population-Based Case Control Study,” J Thorac Oncol, 2007; 2(2):109-14.
  176. Shinohara ET, Gonzalez A, Massion PP, Olson SJ, Albert JM, Shyr Y, Carbone DP, Johnson DH, Hallahan DE, and Lu B: “PDGFR-Beta expression in small cell lung cancer patients,” Int J Radiat Oncol Biol Phys, 2007; 1; 67(2):431-7.
  177. Lovvorn HN 3rd, Boyle S, Shi G, Shyr Y, Wills ML, Perantoni AO, de Caestecker M: “Wilms’ tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED 1.” J Pediatr Surg, 2007; 42(3):474-81.
  178. Cmelak AJ, Murphy BA, Burkey B, Douglas S, Shyr Y, and Netterville J: “Taxane-based chemoirradiation for organ preservation with locally advanced head and neck cancer: Results of a phase ll multi-institutional trail,” Head Neck, 2007; 29(4):315-24.
  179. Willey CD, Murphy BA, Netterville JL, Burkey BB, Shyr Y, Shakhtour B, Kish B, Raben D, Chen C, Song JI, Kane MA, Cmelak AJ: “A Phase II multi-institutional trial of chemoradiation using weekly docetaxel and erythropoietin for high-risk postoperative head and neck cancer patients.” Int J Radiat Oncol Biol Phys, 2007; 67(5):1323-31.
  180. Shin A, Shrubsole MJ, Ness RM, Wu H, Smalley WE, Shyr Y, Zheng W: “Meat and meat-mutagen intake, doneness Preference and the risk of Colorectal Polyps: The Tennessee Colorectal Polyp Study,” Int J of Cancer, 2007; 121(1):136-42.
  181. Murff HJ, Shrubsole MJ, Smalley WE, Wu H, Shyr Y, Ness RM, Zheng W: “The interaction of age and hormone replacement therapy on colon adenoma risk,” Cancer Detect Prev, 2007; 31(2):161-5.
  182. Cheng N, Chytil A, Shyr Y, Moses HL: “Enhanced HGF signaling by type II TGF-ß receptor knockout fibroblasts promotes mammary tumorigenesis,” Cancer Research, 2007; 67(10):4869-77.
  183. Hoshino A, Yee CJ, Campbell M, Woltjer RL, Townsend RL, Riet van Der Meer, Shyr Y, Holt JT, Moses HL, and Jensen RA: “Effects of BRCA1 Transgene Expression on Murine Mammary Gland Development and Mutagen-Induced Mammary Neoplasia,” Int J of Cancer, 2007; 3(5):281-91.
  184. Agulnik M, da Cunha Santos G, Hedley D, Nicklee T, Dos Reis PP, Ho J, Pond GR, Chen H, Chen S, Shyr Y, et. al.: “Predictive and pharmacodynamic biomarker studies in tumor and skin tissue samples of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with erlotinib,” J CLin Oncol, 2007; 25(16):2184-90.
  185. Li JQ, Xu BJ, Shakhtour B, Deane N, Merchant N, Heslin MJ, Washington K, Coffey RJ, Beauchamp RD, Shyr Y, Billheimer D: “Variability of in situ proteomic profiling and implications for study design in colorectal tumors,” Int J Oncol, 2007; 31(1):103-11.
  186. Kantrow SM, Boyd AS, Ellis DL, Nanney LB, Richmond A, Shyr Y, Robbins JB: “Expression of activated Akt in benign nevi, Spitz nevi and melanomas,” J Cutan Pathol, 2007; 34 (8): 593-6.
  187. Jiang A, Pan W, Milbauer LC, Shyr Y, Hebbel RP: “A practical question based on cross-platform microarray data normalization: are BOEC more like large vessel or microvascular endothelial cells or neither of them?” J Bioinformatics and Comp Bio, 2007; 5 (4): 875-93.
  188. Chen S, Hong D, Shyr Y: “Wavelet-based procedures for proteomic mass spectrometry data processing,” Comp Stat and Data Analysis, 2007; 52 (1): 211-20.
  189. Roberts LJ 2nd, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JD: “The relationship between dose of vitamin E and suppression of oxidative stress in humans,”
Free Radic Biol Med. 2007;43(10):1388-93. Epub 2007 Jul 4.
  1. Yildiz PB, Shyr Y, et. al.: “Diagnostic accuracy of MALDI mass spectrometry analysis of unfractionated serum in lung cancer,” J Thorac Oncol. 2007;2(10):893-901.
  2. Albert JM, Gonzalez A, Massion PP, Chen H, Olson SJ, Shyr Y, et. al.: “Cytoplasmic clusterin expression is associated with longer survival in patients with resected non small cell lung cancer,” Cancer Epidemiol Biomarkers Prev. 2007;16(9):1845-51.
  3. Fei Y and Shyr Y: “Balanced two-stage design for phase II clinical trials,” Clinical Trials: J Soc Clin Trials, 2007;4(5):514-24.
  4. Sinsakul M, Sika M, Rodby R, Middleton J, Shyr Y, et. al.: “A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease,” Am J Kidney Dis. 2007;50(6):646-51.
  5. Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE, Li M, Shyr Y, Zheng W: “The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk,” Am J Clin Nutr. 2007;86(3):743-51.
  6. Tang YW, Li H, Wu H, Shyr Y, Edwards KM: “Host single-nucleotide polymorphisms and altered responses to inactivated influenza vaccine,” J Infect Dis. 2007;196(7):1021-5. Epub 2007 Aug 29.
  7. Wu H, Muscato NE, Gonzalez A, Shyr Y: “An EGFR and AKT Signaling Pathway was Identified with Mediation Model in Osteosarcomas Clinical Study,” Biomarker Insights. 2007;2:469-76.
  8. Guix M, Granja ND, Meszoely I, Adkins T, Wieman B, Frierson K, Sanches V, Sanders ME, Mayer IA, Pestano G, Shyr Y,et. al.: “Short Pre-Operative Treatment With Erlotinib Inhibits Tumor Cell Proliferation in Hormone Receptor-Positive Breast Cancers,” J Clin Oncol. 2008;Jan 7.

Book Chapters

  1. Shyr Y (2002). Statistics with Applications to the Biomedical Science. Tamkang Chair Lecture Series 132. Tamkang University, Taipei, Taiwan.
  2. Shyr Y and Kyung Mann Kim (2003) "Weighted Flexible Compound Covariate Method for Classifying Microarray Data" in: A Practical Approach to Microarray Data Analysis (Berrar, D., ed.), Kluwer Academic Publishers, Norwell, MA, USA
  3. Shyr Y (2006) "Statistical Approaches for High Dimensional Data Derived from High Throughput Assays" in: Handbook of Statistics in Clinical Oncology 2nd edition (Crowley J, ed.), Chapman and Hall/CRC, Boca Raton, FL, USA.
  4. Hong D and Shyr Y (2007) Quantitative Medical Data Analysis Using Math Tools and Statistical Techniques, World Scientific Publication, Singapore, (ISBN: 978-981-270-461-0).
  5. Hong D and Shyr Y (2007) "Mathematical Framework and Wavelets Applications in Proteomics for Cancer Study" in: Handbook of Cancer Models with Applications to Cancer Screening, Cancer Treatment and Risk Assessment, (Wai-Yuan Tan and Leonid Hannin Eds.), World Scientific Publication, Singapore.
  6. Hong D, Li HM, Li M, and Shyr Y (2007) "Evolution Algorithm and Recent Progress on Proteomic Data Preprocessing Using" in: Quantitative Medical Data Analysis Using Math Tools and Statistical Techniques, pp. 155-174. World Scientific Publication, Singapore.
  7. Hong D, Yuan X, and Shyr Y (2007) "Survival Model and Estimation for Lung Cancer Patients" in: Quantitative Medical Data Analysis Using Math Tools and Statistical Techniques, pp195-216. World Scientific Publication, Singapore.

Memberships

  1. American Statistical Association
  2. International Biometrics Society
  3. Institute of Mathematical Statistics
  4. Society for Clinical Trials
  5. Society for Epidemiologic Research
  6. International Chinese Statistical Association


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