Aixiang Jiang, MS Assistant in Biostatistics
Email: aixiang.jiang@vanderbilt.edu Phone: 615.936.7360 Fax: 615.936.2602	Vanderbilt University School of Medicine Department of Biostatistics 551 Preston Research Building Nashville, TN 37232-6848

Education

• Master of Science in biostatistics, October 2005, University of Minnesota
• Master of Science in software engineering, May 2002, University of St. Thomas
• Master of Science in pharmacology with minor in statistics, May 2002, University of Minnesota
• Master of Science in quantitative genetics, July 1991, China

Journal Reviewer

• Bioinformatics (http://bioinformatics.oxfordjournals.org/)
• Methods of Information in Medicine (http://www.schattauer.de/index.php?id=704)
• Cancer Informatics (http://la-press.com/journal.php?pa=description&journal_id=10)
• Journal of Vascular Research (http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=224160)

Research Interests

• Microarray
• Normalization and analyses of Affymetrix, cDNA, CGH, SNP, and Chip-on-chip data.
• Single gene, groups of genes or signal pathways testing.
• False discovery rate.
• Copy number analysis based on CGH or SNP intensity data.
• Clustering and classification.
• Correlation.
• Random forest.
• MDS (multidimensional scaling).
• SVM (support vector machine).
• 3D rotatable plot display.

Talks

• GIBH (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences), Introduction of experiment design and data analyses, July 2009
• GIBH (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences), Discussion of Microarray Analysis Trends with Case Studies, Dec 2008
• SCBIT (Shanghai Center for Bioinformation Technology), New local false discovery rate estimation method: COfdr, Dec 2008
• ENAR 2007, 2008, 2009
• JSM 2007
• Departmemt seminars: Nov 2006, Sep 2007
• NSP: Nov 2007

Software

• SampleRcodecontrolOnlyfdr111308.r:

Publications in English

• Massion PP, Zou Y, Chen H, Jiang A Coulson P, Amos CI, Wu X, Wistuba I, Wei Q, Shyr Y, Spitz MR, smoking-Related Genomic Signatures in Non-Small Cell Lung Cancer, Am J Respir Crit Care Med. 2008 Dec 1;178(11):1164-72
• C Milbauer L, Wei P, Enenstein J, Jiang A, Hillery CA, Scott JP, Nelson SC, Bodempudi V, Topper JN, Yang RB, Hirsch B, Pan W, Hebbel RP ( L.C.M, P.W., J.E., and A.J. contributed equally to this work), Genetic endothelial systems biology of sickle stroke risk. Blood. 2008 Apr 1;111(7):3872-9
• Hebbel RP, Wei P, Jiang A, et al, Genetic influence on the systems biology of sickle stroke risk detected by, endothelial gene expression, Blood, 2007 Nov 16; 110(11): 132A
• Jiang A, Pan W, Milbauer LC, Shyr Y, Hebbel RP, A practical question based on cross-platform microarray data normalization: are BOEC cells more like large vessel or microvascular endothelial cells or neither of them? Journal of Bioinformatics and Computational Biology, vol5 no4 August 2007, p875-893
• Shames DS, Girard L, Gao B, Sato CM, Shivapurkar N, Jiang A, Perou CM, Kim YH, Pollack JR, Fong KM, Lam CL, Wong M, Shyr Y, Nanda R, Olopade OI, Gerald W, Euhus SM, Shay JW, Gazdar AF, Minna JD, A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Noval Methylation marjers for Multiple Malignancies, Plos Medicine, 3(12): 2244-2263 Dec 2006
• Pan W, Shen X, Jiang A, Hebbel RP, Semi-Supervised Learning via Penalized Mixture Model with Application to Microarray Sample Classification, Bioinformatics, vol 22 no. 19 2006, p2388-2395
• Hebbel RP, Jiang A, Hillery CA, et al. Genetic influence on the systems biology of sickle stroke risk detected by endothelial gene expression. BLOOD 106 (11): 26A-26A 73 Part 1 NOV 16 2005
• Wilson MJ, Jiang A, Wiehr C, Wang X, Sinha AA, Pei D, Limited processing of pro-matrix metalloprotease-2 (gelatinase A) overexpressed by transfection in PC-3 human prostate tumor cells: association with restricted cell surface localization of membrane-type matrix metalloproteinase-1, Journal of Andrology, Vol. 25, No. 2, March/April 2004, 274-85
• Jiang A, Pei D, Distinct roles of catalytic and pexin-like domains in membrane-type matrix metalloproteinase (MMP)-mediated pro-MMP-2 activation and collagenolysis, J. Biol. Chem., Vol. 278, Issue 40, 38765-38771, October 3, 2003
• Jiang A, Lehti K, Wang X, Weiss SJ, Keski-Oja J, Pei D, Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13693-8
• Kang T, Yi J, Yang W, Wang X, Jiang A, Pei D, Functional characterization of MT3-MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3-D collagen lattice, FASEB Journal. 2000;14:2559-2568
• Lei J, Jiang A, Pei D, Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183, Biochim Biophys Acta. 1998 Dec 22;1443(3):400-6

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