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Benjamin R. Saville, Ph.D.

Assistant Professor

Saville_Benjamin_Faculty_Photo.jpg
E-mail: b.saville [at] vanderbilt [dot] edu
Phone: 615.343.3624
Fax: 615.343.4924
Office: 11128A
Vanderbilt University School of Medicine
Department of Biostatistics
2525 West End, Ste. 11000
Nashville, TN 37203

Research Interests

  • Clinical trials
  • Bayesian adaptive clinical trials
  • Nonparametric randomization-based analysis of covariance
  • Bayesian model selection in hierarchical linear models

Curriculum Vitae

Education

  • PhD, Biostatistics 2008
    * University of North Carolina at Chapel Hill
    * Dissertation: Bayesian Multilevel Models and Medical Applications
    * Advisor: Dr. Amy H. Herring

  • MS, Biostatistics 2004
    * University of North Carolina at Chapel Hill
    * Thesis: A Statistical method for comparing randomized treatments for favorable response during the last t times of assessment for clinical trials with random censoring of follow-up time
    * Advisor: Dr. Gary G. Koch

  • BS, Statistics, Magna Cum Laude, 2002
    * Brigham Young University, Provo, UT

Work Experience

  • Vanderbilt University
    • Assistant Professor, Department of Biostatistics (2008-present)
    • Assistant Professor (Secondary Appointment), Department of Biomedical Engineering, (2009-2013)
    • Assistant Professor, Division of Cancer Biostatistics, Department of Biostatistics (2011-present)
    • Member, Vanderbilt Center for Quantitative Sciences (2011-present)

Areas of Collaboration

Teaching

Peer Reviewed Publications

  1. Agarwal H.S., Wolfram K.B., Saville B.R., Donahue B.S. Bichell D.P. (2013). Postoperative complications and association with outcomes in pediatric cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery (in press).
  2. Bremer A.A., Stanhope K.L., Graham J.L., Cummings B.P., Ampah S.B., Saville B.R., Havel P.J. (2013). Fish Oil Supplementation Ameliorates Fructose-Induced Hypertriglyceridemia and Insulin Resistance in Adult Male Rhesus Macaques. The Journal of Nutrition doi: 10.3945/jn.113.178061.
  3. Falaiye T.O, Mitchell K.R., Zengqi L., Saville B.R., Moulton, D.E., Schwartz, D.A., Wilson, K.T., Rosen, M.J. Outcome following Infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant inflammatory bowel disease. Journal of Pediatric Gastroenterology & Nutrition (in press).
  4. Agarwal H.S, Wolfram K.B., Slayton J.M., Saville B.R., Cutrer W.B., Bichell D.P., Harris Z.L., Barr F.E., Deshpande J.K. (2013). Template of patient summaries facilitate education and outcomes in pediatric cardiac surgery unit. Journal of Cardiovascular and Thoracic Surgery (in press).
  5. Dalabih A.R., Bondi S.A., Harris Z.L., Saville B.R., Wang W., Arnold D.H. (2013). Aminophylline infusion for status asthmaticus in the pediatric critical care unit setting is indepen- dently associated with increased length of stay and time for symptom improvement. Pulmonary Pharmacology and Therapeutics (in press).
  6. Castel L.D., Hartmann K.E., Mayer I.A., Saville B.R., Alvarez J., Boomershine, C.S., Abramson V.G., Chakravarthy A.B., Friedman D.L., Cella D.F. (2013) Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort. Cancer (in press).
  7. Linder J.E., Kraft D.C., Mohamed Y., Zengqi L., Heil L., Saville B.R., Williams J.V., Miller K. (2013). HRV-C is not a new virus: age, season, and year are associated with HRV species in a 21-year prospective pediatric cohort. The Journal of Allergy and Clinical Immunology (in press).
  8. Schulert G.S., Zengqi L., Wingo T., Tang Y., Saville B.R., Hain P.D. (2013). Role of a respiratory viral panel in the clinical management of pediatric inpatients. The Pediatric Infectious Disease Journal (in press).
  9. Watson A., Saville B.R., Zengqi L., Walsh W (2013). Itís not the ride: Inter-hospital transport is not an independent risk factor for intraventricular hemorrhage among very low birth weight infants. Journal of Perinatology (in press).
  10. Arnold D.H., Saville B.R., Wang W., Hartert T.V. (2013). Performance of the acute Asthma Intensity Research Score (AAIRS) for acute asthma research protocols. Annals of Allergy, Asthma & Immunology (in press).
  11. Dunn S.R., Ryder A.B., Tollefson S.J., Xu M., Saville B.R., and Williams J.V. (2013). Seroepidemiologies of Human Metapneumovirus and Respiratory Syncytial Virus in Young Children, Determined with a New Recombinant Fusion Protein Enzyme-Linked Immunosorbent Assay. Clin. Vaccine Immunol 20(10):1654. DOI:10.1128/CVI.00750-12.
  12. Shoemaker A.H., Lomenick J.P, Saville B.R., Wang W., Buchowski M.S., Cone R.D. (2013). Energy expenditure in obese children with pseudohypoparathyroidism type 1a. International journal of Obesity, DOI: 10.1038/ijo.2012.200.
  13. Hussey M.A., Koch, G.G., Preisser J.S., Saville B.R. (2013). Analysis of Matched Studies with Dichotomous Outcomes Using Nonparametric Randomization-Based Analysis of Covariance. Statistics in Biopharmaceutical Research (in press).
  14. Saville B.R., Koch G.G (2013). Estimating covariate-adjusted log hazard ratios in randomized clinical trials using Cox proportional hazards models and nonparametric randomization based analysis of covariance. Journal of Biopharmaceutical Statistics 23 (2): 447-490.
  15. Lomenick J.P., Wang L., Ampah S.B., Saville B.R., Greenwald F.I. (2013). Generic Levothyroxine Compared with Synthroid in Young Children with Congenital Hypothyroidism. The Journal of Clinical Endocrinology & Metabolism 98(2):653-658.
  16. Hain P.H., Gay J.C., Berutti T.W., Whitney G.M, Wang W.W., Saville B.R. (2013). Preventability of early readmissions at a childrens hospital. Pediatrics 131(1):e171-e181.
  17. Drayna P.C., Estrada C., Wang W., Saville B.R., Arnold D.H. (2012). Ketamine is not associated with clinically important elevation of intraocular pressure during procedural sedation. The American Journal of Emergency Medicine 30(7):1215-1218.
  18. Agarwal H.S., Saville B.R., Slayton J.M., Donahue B.S., Daves S., Christian K.G., Bichell D.P., Harris Z.L. (2012). Standardized post-operative handover process improves outcomes in intensive care unit: a model for operational sustainability and improved team performance. Critical Care Medicine 40(7): 2109-2115.
  19. Mathew R., Hernanz-Schulman M., Wilkins S., Wang W., Saville B.R., Bremer A.A. (2012). Changes in carotid artery sonogram in premature pubarche. Journal of pediatric endocrinology and metabolism 25(1-2):139-145.
  20. Jimenez-Truque N., Tedeschi S., Saye E.J., McKenna B.D., Langdon W., Wright J.P., Alsentzer A., Arnold S., Saville B.R., Wang W., Thomsen I., Creech C.B. (2012). Relationship between maternal and neonatal staphylococcus aureus colonization. Pediatrics 129(5):e1252-e1259.
  21. Mathew R.P., Johnson B.D., Wang W., Saville B.R., Bremer A.A (2012). How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test (GHST). Journal of Pediatric Endocrinology and Metabolism 25(7-8):733-739.
  22. Albers E., Donahue B.S., Milne G., Sanchez S., Saville B.R., Wang W., Baldwin S., Bichell D., McLaughlin B. (2012). Perioperative plasma F2-isoprostane levels correlate with markers of impaired ventilation in infants with single ventricle physiology undergoing stage II surgical palliation on cardiopulmonary bypass. Pediatric Cardiology 33:562-568.
  23. Bremer A.A., Stanhope K.L., Graham J.L., Cummings B.P., Wang W., Saville B.R., Havel P.J. (2011). Fructose-fed rhesus monkeys: A nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes. Clinical and Translational Science 4(11):243-252.
  24. Saville B.R., Herring A.H., Kaufman J.S. (2011). Assessing variance components in multilevel linear models using approximate Bayes factors: A case study of ethnic disparities in birthweight. Journal of the Royal Statistical Society, Series A 174(3):785-804.
  25. Saville B.R., LaVange, L.M., Koch G.G (2011). Estimating covariate-adjusted incidence density ratios for multiple intervals using nonparametric randomization-based ANCOVA. Statistics in Biopharmaceutical Research 3(2):242-252.
  26. Moodie P.F., Saville B.R., Tangen C.M, Koch G.G. (2011). Estimating covariate-adjusted log hazards ratios for multiple time intervals in clinical trials using nonparametric randomization-based ANCOVA. Statistics in Biopharmaceutical Research 3(2):232-241.
  27. Israel S.W., Roofe L.R., Saville B.R., Walsh W.F. (2011). Improvement in antenatal diagnosis of critical congenital heart disease implications for postnatal care and screening. Fetal Diagnosis and Therapy 30(3):180-183.
  28. Gay J.C., Hain P.D., Grantham J.A., Saville B.R. (2011). Epidemiology of 15 day readmissions to a childrenís hospital. Pediatrics 127(6):e1505-e1512.
  29. Saville B.R., Kim, Y.S., Koch, G.G. (2011). Graphical displays for clarifying how allocation ratio affects total sample size for the two sample logrank test. Pharmaceutical Statistics 10(1):40-44.
  30. Reich S.M, Bickman B., Saville B.R., Alvarez J. (2010). The Effectiveness of baby books for providing pediatric anticipatory guidance to new mothers. Pediatrics, 125(5):997-1002.
  31. Saville B.R., Herring A.H, and Koch G.G. (2010). A robust method for comparing two treatments in a confirmatory clinical trial via multivariate time-to-event methods that jointly incorporate information from longitudinal and time-to-event data. Statistics in Medicine, 29(1):75-85.
  32. Goldberg, J.F., Calabrese J.R., Saville B.R., Frye M.A., Ketter T.A., Suppes T. (2009). Mood stabilization during acute and continuation phase treatment for bipolar I disorder with lamotrigine or placebo. The Journal of Clinical Psychiatry 70(9):1273-80.
  33. Saville B.R., Herring A.H (2009). Testing random effects in the linear mixed model using approximate Bayes factors. Biometrics 65:369-376.
  34. Castel L.D., Saville B.R., DePuy V., Godley P.A., Hartmann K.E., Abernethy A.P. (2008). Racial differences in pain over one year among women with metastatic breast cancer: a hazards analysis of interval-censored data. Cancer 112(1):162-70.
  35. Whitaker J., Moy S., Saville B.R., Godfrey V., Nielsen J., Bellinger D., Bradfield J. (2007). The effect of cage size on reproductive performance and behavior in C57BL/6 mice. Lab Animal Journal 36(10):32-39.
  36. Castel L.D., Abernethy A.P., Li Y., DePuy V., Saville B.R., Hartmann K.E. (2007). Hazards for pain severity and pain interference with daily living, with exploration of BPI cutpoints, among women with metastatic breast cancer. Journal of Pain and Symptom Management 34(4):380-92.

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