General Statistical Ideas

• Glossary of Statistical Terms
• Medical Citations for Statistical Issues | Older Quick Version | Articles Compiled by Vanderbilt Kennedy Center
• Clinical Trials Methodology
• Manuscript Checklist for Documenting or Avoiding Statistical Errors
• Doug Altman's The Scandal of Poor Medical Research
• Waterboarding and Wilcoxon: What Medical Researchers Might Learn About Statistics From the CIA by Andrew Vickers
• Emanuel, Wendler, and Grady's What Makes Clinical Research Ethical?
• Statistics Notes in the British Medical Journal
• Translating statistical findings into plain English
• Interesting statistics articles from the BBC
• Miscellaneous Problems to Avoid and our Checklist
• Recommendations about Statistical Software
• Severe hazards of using Excel for statistical calculations
• Stats Overview for Clinical Researchers
• The 3/n rule

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Statistical Thinking in Biomedical Research Short Course

• Overview and Target Audience
• Schedule
• Syllabus, Objectives, Handouts, and Readings
• Discussion Board
• Checklist for Course Organizer
• Checklist for Participants
• Notes for Instructors

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Supplementary Handouts

• The End of Statistical Significance? by Jonathan Sterne, Department of Social Medicine, University of Bristol UK
• Introduction to Statistical Concepts (Frank Harrell) and Clinical Trials and Observational Studies (Viktor Bovbjerg, University of Virginia)
• The Basic Logic in Statistical Inference (Rob Abbott, University of Virginia)
• Principles of Experimental Design (Mark Conaway, University of Virginia; also contains some material on repeated measurements and dropouts). There are also older separate versions of Principles of Experimental Design (Mark Conaway) and Repeated Measures Design (Mark Conaway)
• Experimental Design (Jim Patrie, University of Virginia; slides contain description of statistical models useful for analyzing experimental data).
• Bayesian Methods for Clinicians
• Outline of the Bayesian Approach to Randomized Clinical Trials (FE Harrell and M Peruggia)
• Multivariable Modeling Issues
• How Should Change be Measured? (NOTE: Contained in Introduction to Statistical Concepts)
• Analysis of repeated measurements (serial or longitudinal data) (FE Harrell 1987)
• Analysis of Observer Variability (FE Harrell 1987)
• Reporting Results (Gina Petroni, University of Virginia)
• Possible agenda for a short course or research retreat to be offered to clinical and basic science departments

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#BiostatClin

Introduction to Biostatistics for Clinical Investigators

Course for Clinical Pharmacology Fellows Fall 2009 - Spring 2010

• 449 PRB, 12:30 - 1:30, Thursdays

Instructors

• Chris Slaughter DrPH, Assistant Professor of Biostatistics
  • mailto:james.c.slaughter@vanderbilt.edu; D-2207 Medical Center North; 322-0439
• Frank Harrell PhD, Professor of Biostatistics, Chairman, Dept. of Biostatistics
  • mailto:f.harrell@vanderbilt.edu; S-2323 Medical Center North; 322-2001

Syllabus

Textbook and reading materials

• [EMS] Essential Medical Statistics Kirkwood and Sterne
• [B] Biostatistics: A Guide to Design, Analysis, and Discovery Forthofer et. al
• [SN] Statistics Notes. Fifty-five (and counting) valuable short articles on misuses and correct uses of statistics in medical research.
• [LHSP] Little Handbook of Statistical Practice
• [SP] Statistical Problems to Document and to Avoid. A collection of misuses of statistics.
• [H] Handouts
• Glossary of Statistical Terms
• T-test examples, Tests of proportions example
• Power and Sample Size Estimation Software
• Exercises

Lectures

• Key concepts covered during each lecture with review questions

Student presentations

• One fellow present an introduction to the day's topic at the start of class
• Each presentation should last 15-20 minutes
• Before class, fellows should have read all of the assigned material, but do not try to cover every idea during the student presentation. It is better to provide a good, thorough introduction rather than a brief overview of all topics.
• If appropriate, discuss the portions of the topic that pertain to your research or recent papers that you have read. One nice way of organizing a lecture is to start with a specific example (given in the student presentation), continue with general applications and ideas (handled by the instructors), and finishing with more specifics (by the instructors).
• Highlight any areas that you think are unclear and require further explanation
• If you need assistance getting started, the instructors have provided a set of learning objectives that will be covered each lecture. Again, you do not need to cover all of these ideas in your presentation, but it can be a useful starting point.

Instructor Notes and Plans for Upcoming Course

Additional Material from Previous Course

• Syllabus for biostatistics component
• Handout for session 2:Probability and Estimation
• Quiz and answers for session 2
• Handout for session 5:Regression and Correlation
• Quiz and answers for session 5
• Statistical Calculators
• Dandelions: A good way to present point estimates
• An interactive demonstration of the meaning of confidence intervals
• Slides from Mimi Lam MD explaining the purpose of the Kaplan-Meier estimator

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Links to Other Sites

• St. George's Hospital Medical School Statistics Guide for Research Grant Applications, including links to Randomization Software and Services
• Canadian Medical Association Statistics and research methods articles
• British Medical Journal's Statistics at Square One
• NIDCR NERI Symptom research site, with much material related to clinical research methodology and prognostic modeling
• Statistics sites, compiled by Pat Letendre, Medical Laboratory Science, University of Alberta
• Exploring Data - web-based curriculum for introductory statistics from Rex Boggs of Education Queensland, Australia
• Rice University Virtual Lab in Statistics (includes HyperStat Textbook)
• Susan Holmes' graphical applets for teaching probability and statistical concepts
• University of Alabama in Huntsville Virtual Laboratory in Probability and Statistics
• Journal of Statistical Education
• StatSoft Electronic Statistics Textbook
• CyberGnostics Electronic Statistics Textbook Project
• UC Berkeley's Tools for an Interactive Learning Environment
• Charles Annis' interactive demonstration of the central limit theorem and other information about statistics in engineering
• Gary McClelland's Java applet demonstrating the information loss from dichotomizing a continuous variable
• Jerry Dallal's Little Handbook of Statistical Practice
• American Psychological Association Guidelines for Statistical Methods in Psychology Journals
• NIST Sematech Engineering Statistics Handbook
• Frequently Asked Statistical Questions by Rich Ulrich, University of Pittsburgh
• Dartmouth Chance Case Study Quantitative Literacy Course
• Peter Diggle's highly informative web site for spatial statistics
• Gillian Raab's teaching material on Bayesian inference and the use of BUGS Bayesian analysis software
• Milo Schield's Statistical Literacy and Evidential Statistics Material
• Mike Fuller's List of Statistical Lists
• Cambridge MRC Biostatistics Unit
• Bland and Altman's material on assessing agreement and accuracy
• FE Harrell's bibliographic database

-- FrankHarrell - 10 Feb, 26-27 Jun, 13 Aug 2004, 13 Feb 2005, 24 Dec 2006, 25 Sep 2007, 7 Apr 2008, 26 Feb, 18 Aug 2009
-- ColeBeck - 08 Mar 2004

• LTD_Paper.pdf: LTD_Paper.pdf

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