General Statistical Ideas


Statistical Thinking in Biomedical Research Short Course


Supplementary Handouts


Introduction to Biostatistics for Clinical Investigators

Course for Clinical Pharmacology Fellows Fall 2009 - Spring 2010

  • 449 PRB, 12:30 - 1:30, Thursdays

Instructors

Syllabus

Textbook and reading materials

Lectures

  Date To read/do before class Topics Instructor
1 9/3 EMS 1-2; Optionally download R and install the Rcmdr package Course description; Introduction (H1); Data Tips CS & FH
2 9/10 H2, EMS 3-4 Descriptive statistics and distributions; Example Paper; Anscombe's quartet CS & FH
3 9/17 Online statbook Chapter; The Basic Logic in Statistical Inference; H3; EMS8 Ideas Behind Hypothesis Testing FH
  9/24   Journal Club TBA
4 10/1 EMS 6; H3.4 - H3.6; Power and Sample Size Estimation Software 1-sample (paired) t-tests: Power, sample size, confidence intervals, and hypothesis testing; SurfStat p-value calculator CS & FH
5 10/8 EMS 7-8; H3.7 - H3.10; Power and Sample Size Estimation Software 2-sample t-tests: Power, sample size, confidence intervals, and hypothesis testing CS & FH
6 10/15 EMS 34 (particularly 34.2 and 34.3) Finish parametric tests. Also, introduction to study designs including randomized/observational, retrospective/prospective, case-control, crossover, and factorial designs CS & FH
  10/22   Journal Club TBA
7 10/29 BMJ article on odds ratio; H4; EMS 16 Categorical data analysis and tests of proportions (H4): Pearson's Chi-squared test, Fisher's exact test, odds ratios, relative risk, and power/sample size calculations TBA
8 11/5 Parametric vs non-parametric tests; EMS 30.1, 30.2 (through Wilcoxon signed rank test) Non Parametric Tests I: When to use non-parametric methods; Wilcoxon 1-sample test TBA
9 11/12   No course (MSCI conflict) TBA
10 11/19 EMS 30.2, 30.3 Non Parametric Tests II: Wilcoxon 2-sample test, the bootstrap for obtaining confidence intervals TBA
  12/3   Journal Club TBA
11 12/10 Measuring change on twiki; Article on measuring change Measuring Change TBA
12     Correlation TBA
13   Paper using Regression Introduction to regression TBA
14     Analysis of variance (ANOVA), both parametric and non-parametric TBA

Student presentations

  • One fellow present an introduction to the day's topic at the start of class
  • Each presentation should last 15-20 minutes
  • Before class, fellows should have read all of the assigned material, but do not try to cover every idea during the student presentation. It is better to provide a good, thorough introduction rather than a brief overview of all topics.
  • If appropriate, discuss the portions of the topic that pertain to your research or recent papers that you have read. One nice way of organizing a lecture is to start with a specific example (given in the student presentation), continue with general applications and ideas (handled by the instructors), and finishing with more specifics (by the instructors).
  • Highlight any areas that you think are unclear and require further explanation
  • If you need assistance getting started, the instructors have provided a set of learning objectives that will be covered each lecture. Again, you do not need to cover all of these ideas in your presentation, but it can be a useful starting point.
Instructor Notes and Plans for Upcoming Course

Additional Material from Previous Course


Links to Other Sites

-- FrankHarrell - 10 Feb, 26-27 Jun, 13 Aug 2004, 13 Feb 2005, 24 Dec 2006, 25 Sep 2007, 7 Apr 2008, 26 Feb, 18 Aug, 17 Dec 2009, 4 Apr 2012, 16 Sep 2012, 4 Feb 2013, 2014-07-15, 2015-02-14, 2015-02-27, 2015-03-03, 2015-06-26, 2015-09-16, 2017-07-18
-- ColeBeck - 08 Mar 2004

Topic attachments
I Attachment Action Size Date Who Comment
ANOVA-extra.pdfpdf ANOVA-extra.pdf manage 143.4 K 25 Mar 2009 - 08:49 ChrisSlaughter Extra annotated plots to explain ANOVA
Basic.inference.pdfpdf Basic.inference.pdf manage 32.9 K 08 Mar 2004 - 13:20 ColeBeck  
EndOfSignificance.pdfpdf EndOfSignificance.pdf manage 531.1 K 28 Nov 2006 - 21:00 FrankHarrell Jonathan Sterne's Presentation
Fitmaurice-change.pdfpdf Fitmaurice-change.pdf manage 35.6 K 29 Oct 2009 - 14:50 ChrisSlaughter Fitzmaurice article on measuring change
LTD_Paper.pdfpdf LTD_Paper.pdf manage 2066.8 K 10 Sep 2009 - 12:01 ChrisSlaughter  
anscombe.pdfpdf anscombe.pdf manage 80.1 K 10 Sep 2009 - 12:00 ChrisSlaughter Anscombe's quartet demonstrating the need to plot data
bayes.pdfpdf bayes.pdf manage 79.1 K 08 Mar 2004 - 15:53 ColeBeck  
ci2.biostat.syllabus.htmlhtml ci2.biostat.syllabus.html manage 12.3 K 08 Mar 2004 - 13:34 ColeBeck  
ci2.biostat1.pdfpdf ci2.biostat1.pdf manage 833.3 K 18 Feb 2008 - 18:13 FrankHarrell Handout for Introduction to Biostatistics for Clinical Investigators
ci2.probest.answers.pdfpdf ci2.probest.answers.pdf manage 10.9 K 08 Mar 2004 - 13:35 ColeBeck  
ci2.probest.pdfpdf ci2.probest.pdf manage 186.5 K 08 Mar 2004 - 13:35 ColeBeck  
ci2.probest.quiz.pdfpdf ci2.probest.quiz.pdf manage 6.5 K 08 Mar 2004 - 13:35 ColeBeck  
ci2.regcorr.answers.pdfpdf ci2.regcorr.answers.pdf manage 17.2 K 08 Mar 2004 - 13:36 ColeBeck  
ci2.regcorr.pdfpdf ci2.regcorr.pdf manage 395.7 K 08 Mar 2004 - 13:35 ColeBeck  
ci2.regcorr.quiz.pdfpdf ci2.regcorr.quiz.pdf manage 13.7 K 08 Mar 2004 - 13:36 ColeBeck  
code.zipzip code.zip manage 37.0 K 29 Dec 2015 - 16:01 FrankHarrell R Code for chapters in Biostatistics for Biomedical Research
doe.pdfpdf doe.pdf manage 49.8 K 08 Mar 2004 - 13:21 ColeBeck  
dox.rm.pdfpdf dox.rm.pdf manage 124.3 K 08 Mar 2004 - 13:21 ColeBeck  
dox.stat.pdfpdf dox.stat.pdf manage 94.2 K 08 Mar 2004 - 13:21 ColeBeck  
essence.rct.htmlhtml essence.rct.html manage 6.2 K 08 Mar 2004 - 13:22 ColeBeck  
glossary.pdfpdf glossary.pdf manage 208.9 K 26 May 2015 - 22:26 FrankHarrell Glossary of statistical terms
km.lam.pdfpdf km.lam.pdf manage 15.2 K 08 Mar 2004 - 13:36 ColeBeck  
lecture1.htmlhtml lecture1.html manage 29.3 K 08 Mar 2004 - 13:20 ColeBeck  
lecture1.vb.pdfpdf lecture1.vb.pdf manage 22.8 K 08 Mar 2004 - 13:20 ColeBeck  
model.pdfpdf model.pdf manage 82.0 K 08 Mar 2004 - 13:22 ColeBeck  
obsVar.pdfpdf obsVar.pdf manage 621.3 K 25 Sep 2007 - 11:21 FrankHarrell Now contained in bbr.pdf
overview.clin.res.pdfpdf overview.clin.res.pdf manage 389.7 K 22 Apr 2011 - 13:46 FrankHarrell Overview of Biostat for Clinical Researchers
power1.pdfpdf power1.pdf manage 86.1 K 08 Oct 2009 - 12:01 ChrisSlaughter  
proport.pdfpdf proport.pdf manage 37.5 K 18 Dec 2007 - 13:10 ChrisSlaughter Chi2 and Fisher's test of proportions for surgical mortality dataset
reg1.pdfpdf reg1.pdf manage 154.6 K 14 Jan 2010 - 12:18 ChrisSlaughter  
repmeas.PDFPDF repmeas.PDF manage 883.5 K 08 Mar 2004 - 13:21 ColeBeck  
reporting.pdfpdf reporting.pdf manage 18.7 K 08 Mar 2004 - 13:22 ColeBeck  
serialData.pdfpdf serialData.pdf manage 1521.1 K 07 Apr 2008 - 17:09 FrankHarrell Analysis of Repeated Measurements FE Harrell 1987
ttest.pdfpdf ttest.pdf manage 38.1 K 06 Dec 2007 - 14:16 ChrisSlaughter Two Sample and Paired T-test examples using R Sleep data
Topic revision: r159 - 18 Jul 2017, FrankHarrell
 

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