## Dynamite Plots | More

- The height of a bar indicates the mean, and the vertical line on top of it represents the standard deviation (or standard error).
- When sample size is small (e.g., n < 15), a dynamite plot should be replaced by a dot plot in which every data point is represented.
- When sample size is large, a box plot should be used.
- Dynamite plots hide the raw data and typically only show one-sided confidence intervals. They usually assume the confidence interval is symmetric.

### An example:

Means and standard deviations (or standard errors?) of Groups A and B look identical. But what does that mean? Group C and D look identical, too.

The *same* data are shown in a dot plot below.

### A few examples

These may have some other statistical/graphical issues.

- Potti A
*et al.* Genomic signatures to guide the use of chemotherapeutics. Nat Med 2006. 12(11): 1294-1300. PMID: 17057710.
- Stephan MT
*et al.* T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med 2007. 13(12) 1411-1413. PMID 18026115.
- Von Hoff DD
*et al.* Inhibition of the hedgehog patheway in advanced basal-cell carcinoma. N Engl J Med. 2009 361 (12): 1202-1205. PMID 19726763.

### "Beware of Dynamite" poster

http://biostat.mc.vanderbilt.edu/twiki/pub/Main/TatsukiRcode/Poster3.pdf
### Departmental Policy

At a department meeting on 18Oct06, statisticians in the department voted in favor of the

policy regarding dynamite plots:

Dynamite plots often hide important information. This is particularly true of small or skewed data sets. Researchers are highly discouraged from using them, and department members have the option to decline participation in papers in which the lead author requires the use of these plots.

### R code

>>

dot plot