Fei Ye, PhD Instructor in Biostatistics
E-mail: fei.ye@vanderbilt.edu Phone: 615-936-2572 Fax: 615-936-2602	Vanderbilt Ingram Cancer Center Department of Biostatistics 521 PRB Nashville, TN 37232-6848

EDUCATION

Ph.D. in Biostatistics, 07/2007, Arnold School of Public Health, University of South Carolina. Dissertation: Statistical Approaches for High-Dimensional Bioinformatics Data.

M.S.P.H. in Biostatistics, 07/2004, Arnold School of Public Health, University of South Carolina. Master’s thesis: Two-Stage Balanced Design for Phase II Oncology Clinical Trials.

B.S. in Computer Science, 07/2001, Southwest University for Nationalities, China.

PUBLICATIONS

Osusky KL, Hallahan DE, Fu A, Ye F, Shyr Y, Geng L “The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels”. Angiogenesis 2004; 7: 225-33.

Ye F, Guo Y, Lawson A, and Tang J, "Improving tree search in phylogenetic reconstruction from genome rearrangement data". Experimental Algorithms 4525/2007: 352-364.

Ye F and Shyr Y, “Balanced two-stage design for phase II clinical trials”, Clinical Trials 2007; 4(5):514-24.

Frangoul H, AI-Jadiry MF, Shyr Y, Ye F, Shakhtour B, and Al-Hadad SA, “Chemotherapy shortage in Iraq and outcome of childhood acute lymphocytic leukemia”. New England Journal of Medicine 2008; July 24:359 (4):435-437.

Mutter R, Lu B, Carbone DP, Csiki I, Johnson DH, Morrow JD, Sandler AB, Shyr Y, Ye F, Hak Choy “A phase II study of celecoxib in combination with paclitaxel, carboplatin, and radiotherapy for patients with inoperable stage IIIA/B NSCLC”, Clinical Cancer Research 2009; Mar 15;15(6):2158-65.

Guo Y, Ye F, and Tang J, "Phylogenetic Reconstruction with Disk-Covering and Bayesian Approaches," 8th IEEE International Conference on Bioinformatics and Bioengineering (BIBE 2008).

Geng L, Rachakonda G, Morré DJ, Morre DM, Crooks PA, Sonar VN, Roti Roti JL, Rogers B Greco S, Ye F, Salleng K, Freeman ML, and Sekhar KR, “Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature”, The Journal of the Federation of American Societies for Experimental Biology, 2009 Sep; 23(9):2986-95.

Davies SS, Traustadóttir T, Stock AA, Ye F, Shyr Y, Harman SM, and Roberts II LJ, “Forearm ischemia reperfusion unveils diminished capacity of older adults to constrain oxidative insult”, Free Radical Biology and Medicine, 2009 Oct 1;47(7):1014-8.

Lovejoy CA, Xu X, Bansbach CE, Glick GG, Zhao R, Ye F, Sirbu BM, Titus LC, Shyr Y, Cortez D, “Functional genomic screens identify CINP as a genome maintenance protein” – PNAS, accepted.

Ye F, Bauer JA, Wu H, Pientenpol JA, Shyr Y, “Statistical practice in high-throughput siRNA/shRNA screens identifying genes mediating sensitivity to chemotherapeutic drugs” – to be submitted

Bauer JA, Marshall C, Pendleton C, Ye F, Pietenpol JA, “RNAi screening approach to identify paclitaxel sensitizers for use in breast cancer therapy – enhancing paclitaxel sensitivity by identifying novel drug combinations through RNAi screening in breast cancer cell lines” – to be submitted

PRESENTATIONS, SEMINARS, AND LECTURES

Ye F, “Balanced two-stage design for oncology phase II clinical trials”.

Clinical Trials, Vol 1, Supplement 1, 2004; 25^th Annual Meeting of the Society for Clinical Trials, May 2004 - New Orleans, Louisiana.

Ye F, “Particle Filtration Approach of Phylogenetic Reconstruction from Genome Rearrangement Data”. August 2007. – Department of Biostatistics, Vanderbilt University - Nashville, TN.

Ye F, “Two-Stage Clinical Trial Designs for Multiple Endpoints with Correlated Observations”. International Biometrics Society, Eastern North American Region, March 2008 – Arlington, VA.

Ye F, “Design and Analysis of Phase III Clinical Trials”. June 2008. – 2008 Cancer Biostatistics Workshop, Vanderbilt University. Nashville, TN.

Ye F, “Randomization in Clinical Trials”, July 2009. – Research Skills Workshop Series. Vanderbilt Clinical Research Center. Nashville, TN.

Ye F, “Oncology Clinical Trial Design – Phase I, Phase II, and Phase III Trials”, August 2009. – Vanderbilt University School of Medicine, Division of Continuing Medical Education. Nashville, TN.

Ye F, “Statistical Practice in High-Throughput siRNA Screens Identifying Genes Mediating Sensitivity to Chemotherapeutic Drugs”. – scheduled November 2009. – 2009 Cancer Biostatistics Workshop, Vanderbilt University. Nashville, TN.

CONFERENCE ABSTRACTS AND POSTERS

Ewing G, Giglia J, Vusirikala M, Ye F, Shyr Y, Chinratanalab W, Ruffner K, Kassim A, Jagasia M, Engelhardt B, Brandt S, Morgan D, Stein R, Greer J, Schuening F, and Goodman S, “CD34 dose and chronic graft versus host disease (cGVHD) affect survival in allogeneic Peripheral Blood Stem Cell Transplantation (alloPBSCT) following Non-Myeloablative (NM) conditioning: the Vanderbilt University/Nashville VA SCT program experience”. BMT Tandem Meeting of the American Society of Bone Marrow Transplantation, Feb 2007 - Keystone, Colorado.

Ye F, Guo Y, and Tang J, “Improving tree search in phylogenetic reconstruction from genome rearrangement data”. 6th Workshop on Experimental Algorithms, June 2007 - Rome, Italy.

Mutter RW, Csiki I, Ye F, Johnson D, Dang T, Carbone D, Morrow J, Sandler A, Lu B, and Hak Choy “A phase II study of celecoxib in combination with paclitaxel, carboplatin, and radiotherapy for patients with inoperable stage IIIA/B Non-Small Cell Lung Cancer”, International Journal of Radiation Oncology Biology Physics, Vol69,Issue 3, S524, 2007.

Fohn LE, Stricklin G, Robbins J, Shyr Y, Rodriguez A, Ye F, “D2-40 detected lymphatic invasion and sentinel node status in melanoma”, Journal of Cutaneous Pathology 2008; December 36(1):108; The 45^th Annual American Society of Dermatopathology, October 2008 – San Francisco, CA.

Dexheimer JW, Talbot TR, Ye F, Shyr Y, Jones I, Gregg WM, Aronsky D, “Implementing a computerized pneumococcal vaccination reminder system in an emergency Department: A prospective study”, AMIA Annual Symposium Proceedings. 2008 Nov 6:867.

Geng L, Rachakonda G, Morré DJ, Morre DM, Crooks PA, Sonar VN, Roti Roti JL, Rogers B Greco S, Ye F, Salleng K, Freeman ML, and Sekhar KR, “Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature”, RRS 55th Annual Meeting of the Radiation Research Society , October 2009-Savannah GA.

JOURNAL REVIEW

Physiological Genomics; ( Co-reviewed) Clinical Trials, Clinical Cancer Research, Carcinogensis, Journal of Clinical Oncology

RESEARCH PROGRAMS

Grant Proposals as Major Statistician

• “Studying the role of TGF-β in gliomagenesis and the regulation of NSC” (with Dr. Ty Abel)

RESEARCH INTERESTS

• Design and Analysis of Clinical Trials
• Method Development and Analysis of High-Dimensional Bioinformatics Data
• Statistical Analysis and Algorithm Development for Cancer Studies
• Phylogeny Reconstruction of Gene-order/Genome Arrangement Data

VICC Cancer Biostatistics Center