Lily Wang Assistant Professor of Biostatistics Department of Biostatistics Vanderbilt University School of Medicine S-2323 Medical Center North Nashville, TN 37232-2158 lily.wang@vanderbilt.edu phone: (615) 343-3856 fax: (615) 343-4924

Research Interests

• Design and Analysis of Clinical Trials
• Statistical Methods for Systems Analysis of High Throughput Omics Datasets
• Statistical Analysis of Correlated Data (Mixed-Effects Models)
• Models for Extremal Events (maximums, minimums); Extreme Value Theory
• Models for Mixture Distributions

Education

PhD in Biostatistics 2004
School of Public Health, the University of North Carolina at Chapel Hill
Dissertation: Some Statistical Aspects of the Analysis of Genomic Sequences (manuscript)
Advisor: Dr Pranab K Sen

MS in Biostatistics 2000
School of Public Health, the University of North Carolina at Chapel Hill
Advisor: Dr Gary G Koch

BA in Mathematics 1998
School of Arts and Sciences, Temple University

Work Experience

Assistant Professor 2004 - present
Department of Biostatistics, Vanderbilt University

Research Assistant, Student Consultant 1998 - 2004
Biometric Consulting Lab, the Univeristy of North Carolina at Chapel Hill

Publications

Statistical Methods for Systems Analysis of High Throughput Omics Datasets

1. Wang L, Sen PK. Extreme Value Theory in Some Statistical Analysis of Genomic Sequences. Extremes 2005; 8(4):295-310.
2. Wang L, Zhang B, Wolfinger RD, Chen X. An Integrated Approach for the Analysis of Biological Pathways Using Mixed Models. PLoS Genetics 2008; 4(7): e1000115. highlight1 highlight2
3. Statnikov A, Wang L, Aliferis CF. A comprehensive comparison of random forests and support vector machines for microarray-based cancer classification. BMC Bioinformatics 2008,9:319
4. Chen X*, Wang L*, Smith JD, Zhang B (* co-first authors). Supervised Principal Component Analysis for Gene Set Enrichment of Microarray Data with Continuous or Survival Outcomes. Bioinformatics; 2008 24(21):2474-2481
5. Chen X, Wang L. Integrating Biological Knowledge with Gene Expression Profiles for Survival Prediction of Cancer. Journal of Computational Biology; 2009 16(2):265-278
6. Chen X, Wang L, Hu B, Barnard J, Zhu X. Pathway-based Analysis for Genome-wide Association Studies using Supervised Principal Components. In Review
7. Wang L, Chen X, Wolfinger RD, Franklin JL, Coffey RJ, Zhang B. A Unified Mixed Effects Model for Gene Set Analysis of Time Course Microarray Experiments. Statistical Applications in Genetics and Molecular Biology. 2009; 8(1): Article 47
8. Wang L, et al. A Powerful Generalized Linear Mixed Model for Testing Disease Association with Genetic Variants in a Pathway, with Applications to Genome-wide Association Studies. In Preparation

Clinical Neurology, Neuroscience, Psychiatry and others

1. Peltier AC, Garland E, Raj SR, Sato K, Black B, Song Y, Wang L, Biaggioni I, Diedrich A, Robertson D. Distal Sudomotor Findings in Postural Tachycardia Syndrome. Clinical Autonomic Research 2009; (In Press)
2. Wylie C, Hendricks T, Zhang B, Wang L, Lu P, Leahy P, Fox S, Maeno H, Deneris E. Distinct transcriptomes define rostral and caudal serotonin neurons. Journal of Neuroscience. 2009; (In Press)
3. Azar NJ, Lagrange AH, Wang L, Song Y, Abou-Khalil BW. Transient Improvement after Brief Antiepileptic Drug Withdrawal in the Epilepsy Monitoring Unit- Possible Relationship to AED Tolerance. Epilepsia. 2009; (In Press)
4. Peltier A, Smith GA, Russell JW, Sheikh K, Bixby B, Howard J, Goldstein J, Song Y, Wang L, Feldman EL, Singleton RJ. Reliability of quantitative sudomotor axon reflex testing and quantitative sensory testing in neuropathy of impaired glucose regulation. Muscle and Nerve 2009; 39(4): 529-535
5. Mengesha T, Abu-Ata M, Haas KF, Lavin PJ, Sun DA, Konrad PE, Pearson M, Wang L, Song Y, Abou-Khalil BW. Visual Field Defects after Selective Amygdalohippocampectomy and Standard Temporal Lobectomy. Journal of Neuro-Ophthalmology. 2009; (In press)
6. Goldman SE, Surdyka K, Cuevas R, Adkins K, Wang L, Malow BA. Defining the sleep phenotypes in children with autism. Developmental Neuropsychology. 2009; 34(5): 560-573
7. Reed HE, McGrew S, Artibee K, Surdkya K, Goldman SE, Frank K, Wang L, Malow B. Parent-Based Sleep Education Workshops in Autism. Journal of Child Neurology. 2009; (In Press)
8. Malow BA, Crowe C, Henderson L, McGrew SG, Wang L, Song Y, Stone WL. A Sleep Habits Questionnaire for Children with Autism Spectrum Disorders. Journal of Child Neurology 2009; 24(1): 19-24
9. Matrisciano F, Bonaccorso S, Ricciardi A, Panaccione I, Wang L, Ruberto A, Tatarelli R, Nicoletti F, Girardi P, Shelton RC. Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine. Journal of Psychiatric Research 2009; 43(3): 247-254
10. Malow BA, Foldvary-Schaefer N, Vaughn BV, Selwa LM, Chervin RD, Weatherwax KJ, Wang L, Song Y. Treating Obstructive Sleep Apnea in Adults with Epilepsy: A Randomized Pilot Trial. Neurology 2008; 71(8):572-7
11. Selwa LM, Marzec ML, Chervin RD, Weatherwax KJ, Vaughn BV, Foldvary-Schaefer N, Wang L, Song Y, Malow B. Sleep Staging and Respiratory Events in Refractory Epilepsy Patients: Is there a First Night Effect? Epilepsia 2008; 49(12):2063-8
12. Azar NJ, Wright AT, Wang L, Song Y, Abou-Khalil BW. Temporal Pattern of Oxcarbazepine and Phenytoin Withdrawal Seizures during Epilepsy Monitoring. Epilepsy Research 2008; 79(1): 78-83
13. Bagai K, Wilson JR, Khanna M, Song Y, Wang L, Fisher MA. Electrophysiological Patterns of Diabetic Polyneuropathy. Electromyogr Clin Neurophysiol 2008; 48(3-4):139-45
14. Hutchinson KN, Song Y, Wang L, Malow BA. Analysis of Sleep Parameters in Patients with Obstructive Sleep Apnea studied in a Hospital vs. a Hotel-Based Sleep Center. J Clin Sleep Med 2008;4(2):119-22.
15. Azar NJ,Wright AT, Wang L, Song Y, Abou-Khalil BW. Generalized Tonic-clonic Seizures after Acute Oxcarbazepine. Neurology 2008; 70: 2187 - 2188
16. Azar NJ, Tayah TF, Wang L , Song Y, Abou-Khalil BW. Post-ictal Breathing Pattern distinguishes Epileptic from Non-Epileptic Convulsive Seizures. Epilepsia 2008; 49(1):132-137.
17. Fu L, Wang L, Y Aphinyanaphongs, Aliferis CF. Comparison of Impact Factor, Clinical Query Filters, and Pattern Recognition Query Filters in Terms of Sensitivity to Topic. Stud Health Technol Inform. 2007 ;129 :716-20
18. Mcgrew S, Malow BA, Henderson L, Wang L, Song Y, Stone WL. A Developmental and Behavioral Questionnaire for Autism Spectrum Disorders. Pediatric Neurology 2007; 37(2):108-116
19. Bonnin A, Torii M, Wang L, Rakic P, Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nature Neuroscience, 2007; 10: 588 - 597
20. Peltier AC, Consens FB, Sheikh K, Wang L, Song Y, Russell JW. Autonomic Dysfunction in Obstructive Sleep Apnea Is Associated with Impaired Glucose Regulation. Sleep Medicine 2007; 8(2): 149-155.
21. Malow BA, Maezec ML, Mcgrew SG, Wang L, Henderson LM, Stone WL, Characterizing Sleep in Children with Autism Spectrum Disorders: A Multidimensional Approach. Sleep 2006; 28(12): 1563-71.
22. Sloane PD, Beck R, Kowlowitz V, Blotzer AM, Wang L, Akins L, White-Chu F, Mitchell CM: Behavioral coding for evaluation of medical student communication: clarification or obfuscation? Academic Medicine 2004; 79(2):162-170.
23. Glowa P, Frasier PY, Wang L, Eaker K, Osterling W: What happens after we identify intimate partner violence? the family physician's perspective. Family Medicine Journal 2003; 35(10):730-736
24. Sloane PD, Zimmerman S, Suchindran C, Reed P, Wang L, Boustani M, Sudha S: The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances. Annual Review of Public Health 2002; 23: 213-231.
25. Herman-Giddens ME, Wang L, Koch GG: Secondary sexual characteristics in boys: estimates from the National Health and Nutrition Examination Survey III, 1988 - 1994. Archives of Pediatric Adolescent 2001;155(9):1022-1028.

Projects

Department of Neurology (Report)
Department of Obstetrics and Gynecology (2004-2007) (Report)

Kennedy Center for Human Development (Report)
The Vanderbilt Silvio O. Conte Center for Neuroscience Research (Report)

Omics Projects

Clinical Trials

1. Effects of Treating Obstructive Sleep Apnea in Epilepsy. A Multicenter, randomized, double-blind, Phase II trial. PI: Dr Beth Malow.
2. Melatonin for Sleep in Children with Autism: Safety, Tolerability, and Dosing. A dose titration Phase II trial. PI: Dr Beth Malow.
3. Safety and Tolerability of Neurostimulation in Early State Parkinson’s Disease. A prospective, randomized, blinded, single-center phase II pilot trial. PI: Dr David Charles.

Resources for Collaborative Research

Departmental Policies on Collaboration, Consulting and Grants (Policy)
Biostatistics Clinics (Clinics)
How to Prepare Data for Statisticians (courtesy of Daniel W. Byrne, Senior Associate in Biostatistics)
10DataEntryCommandments.doc
spreadsheetfromheaven.xls Spreadsheetfromhell.xls
datadictionary.xls (courtesy of Dr Paul Harris)
Research Electronic Data Capture (REDCap)

Departmental Service

Promotions Committee 2007 - present
Statistician Allocations Committee 2006

Calendars

Biostatistics Brain Institute Neurology Psychiatry Omics Clinics

Presentations

1. Design of clinical studies - case-control study, Vanderbilt University Neurology Department , Oct 12 2006.
2. How to Conduct Statistical Modeling. Research Skills Worksop, Vanderbilt General Clinical Research Center, Oct 15, 2004.
3. Statistical Modeling. Statistical Thinking in Biomedical Research Short Course, Vanderbilt University, Oct 21, 2004.
4. Critical Review of Published Microarray Studies for Cancer Outcome and Guidelines on Statistical Analysis and Reporting, Omics Clinic Journal Club, Feb 6, 2007, with Constantin Aliferis.
5. Pathways to the Analysis of Microarray Data, Statistics and Methodology Core Quantitative Training Series, Vanderbilt Kennedy Center for Human Development, Jan 17, 2007
6. On Methods for Gene Function Scoring as a Means of facilitating the Interpretation of Microarray Results, Omics Clinic Journal Club, Vanderbilt Biostatistics department, Aug 15 2006, with Bing Zhang.
7. Planning Microarray Experiments, Statistics and Methodology Core Quantitative Training Series, Vanderbilt Kennedy Center for Human Development, April 17, 2006.
8. Remote homology detection for biological sequences: theory and applications, Aug 21, 2006. Analysis of Complex Data Sets Conference, Vanderbilt Kennedy Center for Human Development, Aug 21 2006.
9. Some Statistical Aspects of Analysis of Genomic Sequences. (invited presentation) Twelfth Annual International Conference on Statistics, Combinatorics, Mathematics and Applications, Auburn, Alabama, December 2-4, 2005.
10. How to Approach Genetic Sequencing Databases - a Primer, Statistics and Methodology Core Quantitative Training Series, Vanderbilt Kennedy Center for Human Development, Sept 30, 2005.
11. Making Sense of DNA and Protein Sequences, Biostatistics Seminar Series, Vanderbilt Biostatistics Department, Sept 28, 2005.
12. Pharmacogenetics and Drug Development, Computational Genetics Journal Club, Vanderbilt University, April 15, 2005.
13. Approximating Pairwise Alignment Score Distributions. Spring Meeting of the Eastern North American Region of the International Biometric Society (ENAR), Pittsburgh, PA, Mar 20-23, 2005.
14. Some Statistical Aspects of Analysis of Genomic Sequences. Spring Meeting of the Eastern North American Region of the International Biometric Society (ENAR), Pittsburgh, PA, Mar 28-31, 2004.

Reviewers

BMC Bioinformatics, Bioinformatics, Genes (editor), Neurology

Album

Pictures Link

Journals

Biostatistics Journals link

Current Opinions
Neurobiology
Genetics and development
Pharmacology

Omics Research
Omics gateway
Neuroscience gateway
Nature Reviews Neuroscience
Nature Neuroscience
Nature Molecular Systems Biology
Nature Genetics
Nature Reviews Genetics

PLoS Computational Biology
PLoS Genetics
PLoS Biology
PLoS One

PNAS
Bioinformatics
Briefings in Bioinformatics
Nucleic Acids Research
J. Computational Biology

BMC Bioinformatics
Genome Biology
BMC Genomics
BMC Systems Biology