Qingxia (Cindy) Chen, PhD

Associate Professor of Biostatistics

Associate Professor of Biomedical Informatics

Picture of Qingxia Chen
E-mail: cindy dot chen at vanderbilt.edu
Phone: 615.936.8058
Fax: 615.343.4924
Office: 2525 West End, Ste. 11126
Vanderbilt University School of Medicine
Department of Biostatistics
2525 West End, Ste. 11126
Nashville, TN 37203-2158

Research Interests

  • Statistical Analysis with Missing Data
  • Survival Data Analysis
  • Electronic Medical Record
  • Treatment switching/Noncompliance
  • Bayesian Statistics
  • Semiparametric/Nonparametric Method, Robust Analysis
  • and More

Information for Collaborators

Curriculum Vitae

CV (updated Feb 2017)

Publication

Statistical Methodological Papers:
  1. Chen Q., Ibrahim J. G. (2006) "Semiparametric Models for Missing Covariate and Response Data in Regression Models". Biometrics, 62, 177-184.
  2. Chen Q., Zeng, D., Ibrahim, J. G. (2007) "Sieve Maximum Likelihood Estimation for Missing Covariates in Regression Models". Journal of the American Statistical Association. Vol 102, 1309-1318.
  3. Chen Q., Ibrahim, J. G., Chen, M.-H., Senchaudhuri, P. (2008) ''Theory and Inference for Regression Models with Missing Response and Covariates". Journal of Multivariate Analysis. 99(6). 1302-31.
  4. Zeng, D., Chen Q., Ibrahim, J. G. (2009) "Gamma frailty transformation models for multivariate survival times''. Biometrika. 96(2):277-291.
  5. Janssen K.J.M., Vergouwe Y., Donders A.R.T., Harrell F.E. Jr., Chen Q., Grobbee D.E., Moons K.G.M. (2009) "Dealing with missing predictor values when applying clinical prediction models". Clin Chem. 2009 May;55(5):994-1001.
  6. Janssen, K.J.M., Donders, A.R.T., Harrell, F.E., Vergouwe, Y., Chen Q., Grobbee, D.E., Moons, K.G.M. (2010) "Missing covariate data in medical research: To impute is better than to ignore ". J Clin Epidemiol. 63(7):721-7.
  7. Zeng, D., Chen Q.* (2010) "Adjustment for Missingness Using Auxiliary Information in Semiparametric Regression". Biometrics. 66(1):115-22. * Corresponding Author.
  8. Zeng D., Chen Q., Chen M-H, Ibrahim J.G., Amgen Research Group (2012) "Estimating Treatment Effects with Treatment Crossovers via Semi-Competing Risks Models: An Application to a Colorectal Cancer Study''. Biometrika. 2012 99 (1): 167-184. Real Data Analysis codes; Simulation I in zip
  9. Wu H.*, Chen Q.*^, Ware L.B., Koyama T. (2012) "A Bayesian Approach for Generalized Linear Model with an Independent Biomarker Measurement Variable Subject to Detection-Limit -- an Application to Acute Lung Injury". Journal of Applied Statistics. 39(8): 1733-1747. * Co-first author; ^ corresponding author.
  10. Zhang Y., Chen Q., Chen M.-H., Ibrahim J.G., Zeng D., Pan Z, and Xue X. "Bayesian Analysis of Survival Data with Semi-Competing Risks and Treatment Switching''. The 2012 ICSA Applied Statistics Symposium Proceedings.
  11. Chen Q., Zeng D., Ibrahim J.G., Akacha M., and Schmidli H., (2013) "Estimating Time-varying Effects for Overdispersed Recurrent Events Data with Treatment Switching''. Biometrika 2013; 100 (2): 339-354. NIHMSID 529973 http://biomet.oxfordjournals.org/cgi/reprint/ass091?ijkey=B5YaOtKiHLCJ5H5&keytype=ref
  12. Chen Q., Chen M.-H., Ohlssen D., Ibrahim J.G. "Bayesian Modeling and Inference for Clinical Trials with Partial Retrieved Data Following Drop-out''. Statistics in Medicine. 2013; 32(24): 4180-4195.
  13. Chen Q., Ibrahim, J. G. "A Note on the Relationships Between Multiple Imputation, Maximum Likelihood and Fully Bayesian Methods for Missing Responses in Linear Regression Models". Statistics and Its Interface. 2014; 6(3): 315-324.
  14. Zhang Y., Chen M.-H., Ibrahim J.G., Zeng D., Chen Q., Pan Z, and Xue X. " Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching''. Life Data Analysis. 2014; 20(1): 76-105.
  15. Chen Q., Wu H, Ware LB, Koyama T. "A Bayesian approach for the Cox proportional hazards model with covariates subject to detection limit". International Journal of Statistics in Medical Research. 2014; 3(1): 32-43.
  16. Chen Q., May RC, Ibrahim JG, Chu H, Cole SR. "Joint modeling of longitudinal and survival data with missing and left-censored time-varying covariates". Stat Med. 2014 Nov 20;33(26):4560-76.
  17. Zhu H., Ibrahim J.G., Chen Q. "Bayesian Case-deletion Model Complexity and Information Criterion". Statistics and Its Interface. 2014; 7(4); 531-42.
  18. Chen Q., Zeng D., Ibrahim J.G., Chen M.-H., Pan Z., Xue X. "Quantifying the Average of the Time-varying Hazard Ratio via a Class of Transformations". Lifetime Data Anal. 2015 Apr;21(2):259-79.
  19. Chen Q., Nian H., Zhu Y., Talbot H.K., Griffin M.R. and Harrell F.E. Jr "Too Many Covariates and Too Few Cases? -- A Comparative Study". Stat Med. 2016 Nov 10;35(25):4546-4558.
  20. Li R., Cheng Y., Chen Q., Jason F. "Quantile Association for Bivariate Survival Data". Biometrics. 2017 Jun;73(2):506-516.
  21. Diao G, Zeng D, Ibrahim JG, Rong A, Lee O, Zhang K, Chen Q. "Statistical design of noninferiority multiple region clinical trials to assess global and consistent treatment effects". J Biopharm Stat. 2017 Feb 13:1-12. PMID:28296570
Collaborative Papers:
  1. Moul, D., Ombao H., Monk T., Chen Q., Begley A., Buysse D. (2002). ``Masking effects of posture and sleep onset on core body temperature: a circadian rhythm of bedtime temperature drops". Journal of Biological Rhythms, 17, 447-462.
  2. Hall M, Vasko R, Buysse D, Ombao H, Chen Q., Cashmere D, Kupfer D and Thayer J. (2004).``Acute Stress Affects Heart Rate Variability During Sleep". Journal of Psychosomatic Medicine, 66, 56-62.
  3. Joos D., Chen Q., Jirjis J., Johnson KB (2006). ``An Electronic Medical Record in Primary Care: Impact on Satisfaction, Work Efficiency and Clinic Processes". AMIA Annu Symp Proc, 394-8.
  4. Dexheimer J., Jones I., Chen Q., Talbot T., Mason D., Aronsky D. (2006). ``Providers' Beliefs, Attitutes, and Behaviors Prior to Implementing a Computerized Pneumococcal Vaccination Reminder.". Academic Emergency Medicine. Acad Emerg Med, 13(12), 1312-8.
  5. Devin J.K., Blevins L.S., Verity D.K., Chen Q., Bloodworth J.R., Covington J., Vaughan D.E. (2007) ``Markedly Impaired Fibrinolytic Balance Contributes to Cardiovascular Risk in Adults with Growth Hormone Deficiency". Journal of Clinical Endocrinology and Metabolism. 3633-3639.
  6. Ali YS, Rembold KE, Wills MB, Chen Q., Ayers CR, Rembold CM. (2008) ``Clinical significance of mobile carotid echoes''. University of Virginia Journal of Medicine. Oct;4:29-34.
  7. Johnson K., Chark D., MSc, Chen Q., Broussard A., Rosenbloom T. (2008) ``Performing Without a Net: Transitioning Away From a Health Information Technology-Rich Training Environment". Academic Medicine. 83(12),
  8. Shinall M.C., Peters T.R. Zhu Y., Chen Q., Poehling K.A. (2008) ``Potential Impact of Accelerating the Primary Series of Pertussis Vaccine in Infants". Pediatrics. 122(5), 1021-6.
  9. Halasa N., Gerber M., Chen Q., Wright P., Edwards K.(2008) ``Safety and immunogenicity of trivalent inactivated influenza vaccine in infants". Journal of Infectious Diseases. 197(10), 1448-1454.
  10. Devin J.K., Vaughan D.E., Blevins L.S., Chen Q., Covington J., Verity D.K., Young P.P. (2008) ``Low-Dose Growth Hormone Administration Mobilizes Endothelial Progenitor Cells in Healthy Adults". Growth Hormone and IGF Research. 18(3), 253-263.
  11. Miller E.K., Khuri-Bulos N., Williams J.V. Shehabi A.A., Faouri S., Jundi I.A., Chen Q., Heil1 L., Mohamed1 Y., Morin L., Ali A., Halasa N.B. (2009) ``Human Rhinovirus C Associated with Wheezing in Hospitalized Children in the Middle East'',J Clin Virol., 46(1):85-9.
  12. Talbot H.K., Poehling K.A., Williams J.V., Zhu Y., Chen Q., McNabb P., Edwards K.M., Griffin M.R. (2009) ``Influenza in Older Adults: Impact of Vaccination of School Children". Vaccine. 27(13):1923-7.
  13. Stenner S.P., Chen Q., Johnson K.B. (2010) ``The Impact of an Electronic Prescribing Intervention on Generic Medication Prescribing Behavior'', J Am Med Inform Assoc. 17(6):681-8.
  14. Rosenbloom S., McNabb T., Chen Q., An A., Hsu S., Dupont W. (2010) ``Specialized Pediatric Growth Charts For Electronic Health Record Systems: the example of Down Sysdrome''. AMIA Annu Symp Proc. 687-91.
  15. Petty, T., Callahan, S.T., Chen Q., Edwards, K.M., Dempsey, A. (2010) ``Assessment of Parental Acceptance of a Potential Cytomegalovirus Vaccine for Adolescent Females Vaccine''. Vaccine. 28(35):5686-90.
  16. Ali SA, Williams JV, Chen Q., Faori S, Shehabi A, Jundi EA, Khuri-Bulos N, Halasa N. (2010) ``Human Metapneumovirus in Hospitalized Children in Amman, Jordan''. J Medical Virology, 82:1012-6.
  17. Khuri-Bulos N, Williams JV, Shehabi AA, Faouri S, Al Jundi E, Abushariah O, Chen Q., Ali SA, Vermund S, Halasa NB. (2010) ``Burden of RSV in Hospitalized Infants and Young Children in Amman, Jordan'', Scand J Infect Dis., 42(5):368-74.
  18. Li J, Solus J, Chen Q., Rho YH, Milne G, Stein CM, Darbar D. (2010) ``Role of inflammation and oxidative stress in atrial fibrillation''. Heart Rhythm., 7(4):438-44
  19. Talbot H., Griffin M., Chen Q., Zhu Y., Williams J., Edwards K. (2011) ``Effectiveness of Seasonal Vaccine in Preventing Confirmed Influenza-Associated Hospitalizations in Community Dwelling Older Adults". Journal of Infectious Diseases. J Infect Dis. 203(4):500-8.
  20. Griffin M.R., Monto A.S., Belongia E.A., Treanor J.J., Chen Q., Chen J., Talbot H.K., Ohmit S.E., Coleman L.A., Lofthus G., Petrie J.G., Meece J.K., Hall C.B., Williams J.V., Gargiullo P., Berman L.S., and Shay D.K. (2011) ``Effectiveness of Non-adjuvanted Pandemic Influenza A (H1N1) Vaccines in Preventing Medically Attended Pandemic Influenza Virus Associated Acute Respiratory Illness in 4 US Communities''. PLoS One. 2011;6(8):e23085. Epub 2011 Aug 12.
  21. Johnson K.B., Unertl K.M., Chen Q., Lorenzi N.M., Nian H., Mrisse M., (2011) ``Health Information Exchange Usage in Ambulatory Settings: the Who, What and Why''. J Am Med Inform Assoc. 2011 Sep-Oct;18(5):690-7.
  22. Gadd C.S., Ho Y.-X., Cala C.M., Blakemore D., Chen Q., Frisse M., Johnson K.B., (2011) ``Users' perspectives on the usability of a regional health information exchange''. J Am Med Inform Assoc. 2011 Sep-Oct;18(5):711-6. Epub 2011 May 27.
  23. Xu H., Fu Z., Shah A., Chen Y., Peterson N., Chen Q., Mani S., Levy M., Dai Q., Denny J. (2011) ``Extracting and integrating data from entire electronic health records for detecting colorectal cancer cases''. AMIA Annu Symp Proc. 2011;2011:1564-72. Epub 2011 Oct 22.
  24. Frisse M., Johnson K., Nian H., Davidson C., Gadd C.S., Unertl K., Turri P.A., Chen Q., (2011) ``The financial impact of health information exchange on emergency department care''. Am Med Inform Assoc. 2012 May 1;19(3):328-33. PMID: 22058169.
  25. Muldowney J.A.S., Chen Q.,, Blakemore D.L., Vaughan D.E., (2012) ``Pentoxifylline Lowers Plasminogen Activator Inhibitor-1 Levels in Obese Individuals: A Pilot Study''. Angiology. 2012 Feb 17. [Epub ahead of print]
  26. Smith J.P., Haddad E.V., Taylor M.B., Oram D., Blakemore D., Chen Q., Boutaud O., Oates J.A., (2012) ``Suboptimal Inhibition of Platelet Cyclooxygenase-1 by Aspirin in Metabolic Syndrome''. Hypertension. 2012 Mar;59(3):719-25.
  27. Liu M, Shah A, Peterson NB, Dai Q, Aldrich MC, Chen Q, Bowton EA, Liu H, Denny JC, Xu H. A study of transportability of an existing smoking status detection module across institutions. AMIA Annu Symp Proc. 2012. In Press.
  28. Xu H, Aldrich MC, Chen Q, Peterson NB, Dai Q, Levy M, Shah A, Xue H, Li Y, Friedman C, Liu H, Denny JC. Electronic health record data suggests metformin improves cancer survival: A new model for drug repurposing studies. AMIA Annu Symp Proc, In press.
  29. Holinstat M., Colowick N.E., Hudson W.J., Blakemore D., Chen Q., Hamm H.E., Cleator J.H.. (2012) ``Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary intervention on protease-activated receptor-mediated platelet activation''. J Thromb Thrombolysis. 2012 Sep 30; [Epub ahead of print]. PMID: 23054462.
  30. Talbot H.K., Zhu Y., Chen Q., Williams J.V., Shay D., Gri n M.R. (2013) `` Effectiveness of influenza vaccine for preventing laboratory-confirmed influenza hospitalizations in adults, 2011-2012 influenza season". Clinical Infectious Diseases. 56(12):1774-7. PMID: 23449269
  31. Ho Y.-X., Chen Q., Nian H., Johnson K. B. (2013) ``An assessment of pharmacists' readiness for paperless labeling: a national survey''. Journal of the American Medical Informatics Association. [Epub ahead of print]
  32. Mulvaney S.A., Ho Y.-X., Cala C., Chen Q., Nian H., Patterson B., Johnson K.B. (2013) ``Assessing Adolescent Asthma Symptoms and Adherence Using Mobile Phones''. Journal of Medical Internet Research. Accepted.
  33. Mani S, Ozdas A, Aliferis C, Varol A, Chen Q., Carnevale R, Chen Y, Romano-Keeler J., Nian H., Weitkamp J-H. (2013) ``Medical decision support using machine learning for early detection of late onset neonatal sepsis". J Am Med Inform Assoc. 2014 Mar-Apr;21(2):326-36 PMCID:PMC3932458
  34. Silverman H, Ho Y-X, Kaib S, Ellis W, Moffitt M, Chen Q, Nian H, Gadd CS. Training the next generation of physicians: a novel approach to maintaining patient and relationship centered care through EHR ergonomic training and assessment in preclerkship medical education. Acad Med. 2013; To appear.
  35. Smith JC, Denny JC, Chen Q., Nian H, Spickard A, Rosenbloom TS, Miller RA. Lessons learned from developing a drug evidence base to support pharmacovigilance. Applied Clinical Informatics, 2014; Accepted.
  36. Xu H.*, Aldrich M.C.*, Chen Q., ..., Denny J.C. "Metformin reduces cancer mortality: evidence from two large electronic health care systems". J Am Med Inform Assoc. 2014; Accepted. *contributed equally to the work.
  37. Fadugba O.O., Wang L. , Chen Q., Halasa N.B. (2014) "Immune Responses to Pertussis Antigens in Infants and Toddlers after Immunization with Multicomponent Acellular Pertussis Vaccine". Clin Vaccine Immunol.;21(12):1613-9
  38. Jia P., Wang Q., Chen Q., Hutchinson K.E., Pao W. and Zhao Z. (2014) "Detection and Quantification of Mutation Hotspots Through Mutation Set Enrichment Analysis". Genome Biol.;15(10):489
  39. Chen Q., Griffin M.R., Nian H., Zhu Y., Williams J.V., Edwards K.M, Talbot H.K. (2015) "Influenza Vaccine Prevents Medically-Attended Influenza-Associated Acute Respiratory Illness in Adults 50 Years or Older". J Infect Dis. 2015 Apr 1;211(7):1045-50.
  40. Talbot HK, Nian H, Zhu Y, Chen Q, Williams JV, Griffin MR. (2015) "Clinical effectiveness of split-virion versus subunit trivalent influenza vaccines in older adults". Clin Infect Dis. 2015 Apr 15;60(8):1170-5.
  41. Xu H, Aldrich MC, Chen Q, Liu H, Peterson NB, Dai Q, Levy M, Shah A, Han X, Ruan X, Jiang M, Li Y, Julien JS, Warner J, Friedman C, Roden DM, Denny JC. (2015) "Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality." J Am Med Inform Assoc. 2015 Jan;22(1):179-91.
  42. Cronin R.M., Davis S.E. , Shenson J.A., Chen Q., Rosenbloom S.T., Jackson G.P. (2015) "Growth of Secure Messaging Through a Patient Portal as a Form of Outpatient Interaction across Clinical Specialties". Appl Clin Inform. 2015 Apr 29;6(2):288-304.
  43. Shenson J.A., Cronin R.M., Davis S.E., Chen Q., Jackson G.P. (2016) "Rapid Growth of Secure Messaging in a Patient Portal Across Surgical Specialties". Surg Endosc. 2016 Apr;30(4).
  44. Johnson KB, Patterson BL, Ho YX, Chen Q, Nian H, Davison CL, Slagle J, Mulvaney SA. (2016) " The feasibility of text reminders to improve medication adherence in adolescents with asthma"J Am Med Inform Assoc. 2016 May;23(3):449-55.
  45. Talbot HK, Nian H, Chen Q, Zhu Y, Edwards KM, Griffin MR. (2016) " Evaluating the case-positive, control test-negative study design for influenza vaccine effectiveness for the frailty bias". Vaccine. 2016 Feb 28. pii: S0264-410X(16)00200-0. doi: 10.1016/j.vaccine.2016.02.037. [Epub ahead of print] PMID:26930368
  46. Chen Q, Nian H, Zhu Y, Talbot HK. (2016) "Reply to Letter to the Editor: Reply to Sullivan et al." vaccine. Volume 34, Issue 39, 46478.
  47. Chen Y, Lask TA, Mei Q, Chen Q, Moon S, Wang J, Nguyen K, Dawodu T, Cohen T, Denny JC, Xu H. (2017) "An active learning-enabled annotation system for clinical named entity recognition" BMC Med Inform Decis Mak. 2017 Jul 5;17(Suppl 2):82.
  48. Mehta VJ, Chelnis JG, Chen Q, Mawn LA (2017) "Effect of Time to Operative Intervention on Motility Outcomes Following Orbital Floor Fracture Repair in Children", Ophthal Plast Reconstr Surg. 2017 Sep 12. doi: 10.1097/IOP.0000000000000993. [Epub ahead of print]

Teaching

Epid 323 (Spring 2011, 2012): Design and Analysis with Time-to-Event Data

Bios 323 (Fall 2012, 2013, 2014, 2015): Applied Survival Analysis

Education

PhD in Biostatistics 2005
Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill
Dissertation: Theory and Inference for Parametric and Semiparametric Methods in Missing Data Problem

MS in Statistics 2001
Department of Statistics, School of Arts and Sciences, University of Pittsburgh

BA in Statistics 1999
Department of Statistics and Finance, University of Science and Technology of China, P.R.China

Epid 323 (Spring 2011): Design and Analysis with Time-to-Event Data

Topic attachments
I Attachment Action Size Date Who Comment
CV_09282012.pdfpdf CV_09282012.pdf manage 54.2 K 17 Oct 2012 - 11:15 QingxiaChen  
Ch1.pdfpdf Ch1.pdf manage 138.4 K 21 Aug 2014 - 12:58 QingxiaChen  
Cindy_061510.pdfpdf Cindy_061510.pdf manage 93.9 K 25 Mar 2011 - 16:08 QingxiaChen  
Lab10.pdfpdf Lab10.pdf manage 72.3 K 07 Nov 2012 - 12:40 HuiNian  
Lab12.txttxt Lab12.txt manage 3.4 K 24 Nov 2012 - 20:20 HuiNian  
Lab9.pdfpdf Lab9.pdf manage 77.5 K 29 Oct 2012 - 14:30 HuiNian  
Schedule.pdfpdf Schedule.pdf manage 39.3 K 21 Aug 2014 - 11:42 QingxiaChen Schedule for Bios 323 (Fall 2014)
Schedule.xlsxls Schedule.xls manage 12.0 K 21 Aug 2014 - 10:33 QingxiaChen Schedule for Bios 323 (Fall 2014)
Syllabus.pdfpdf Syllabus.pdf manage 45.6 K 21 Aug 2014 - 10:32 QingxiaChen Syllabus for Bios 323 (Fall 2014)
VTEU.projectsummary.0406.xlsxls VTEU.projectsummary.0406.xls manage 25.5 K 22 Apr 2006 - 20:56 QingxiaChen  
bmt.csvcsv bmt.csv manage 7.9 K 01 Nov 2012 - 09:48 HuiNian  
cancer.csvcsv cancer.csv manage 1.2 K 26 Sep 2012 - 10:23 HuiNian  
dialysis.txttxt dialysis.txt manage 1.2 K 26 Sep 2012 - 10:22 HuiNian  
leukemia.csvcsv leukemia.csv manage 0.6 K 10 Oct 2012 - 10:32 HuiNian  
tonguecancer.csvcsv tonguecancer.csv manage 2.9 K 19 Sep 2012 - 09:40 HuiNian  
tonguecancer1.csvcsv tonguecancer1.csv manage 2.1 K 29 Aug 2012 - 08:56 HuiNian  
Topic revision: r190 - 27 Oct 2017, QingxiaChen
 

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