Biostatistical Services | Presentation
The main goal of the Department of Biostatistics is to increase the quality and quantity of research in the School of Medicine. As a basic science of research methodology, biostatistics can benefit research programs and investigators in many ways including
- Developing study and experimental designs that maximize the efficiency, increase interpretability and generalizability, and enhance the ethical conduct of research
- Using modern experimental designs that allow for early termination of experiments when sufficient evidence for effects is demonstrated, or extends experiments when results are equivocal
- Refining measurements to increase precision and sensitivity
- Developing grant proposals and increasing their likelihood of being funded
- Assisting with manuscript writing, increasing the likelihood of acceptance and improving the quality of the result
- Analyzing data in a powerful, robust, and reproducible fashion
- Interpreting results using modern statistical graphics for optimum communication to non-statisticians
- Providing methodologic review and teaching in journal clubs, research conferences, and short courses
- Participating in K award mentoring
- Implementing and running secure web-based research data management systems and archiving research databases
The Department currently has 28
faculty and 20 staff M.S. biostatisticians. Details may be found at http://biostat.mc.vanderbilt.edu.
Ways of Obtaining Biostatistics Support
- Biostatisticians taking part on funded grants and contracts, with funding for appropriate % efforts for PhD and MS biostatisticians
- Collaboration plan, with % efforts of biostatisticians funded by collaborating departments with 1:4 matching funds from the Dept. of Biostatistics
- Cancer Center Biostatistics Center core support from the Division of Cancer Biostatistics in the Dept. of Biostatistics
- Design, Biostatistics, and Clinical Research Ethics core in the Vanderbilt Institute for Clinical and Translational Research (VICTR-CTSA)
- Clinical, community, and translational research proposals, upon approval by the VICTR Scientific Review Committee, result in vouchers for biostatistics help and for the following types of studios: design, analysis, manuscript, and studios for fine-tuning funded grants in their startup phase
- Surgical research that is clinical or translational in nature (i.e., relates to human tissue) uses the VICTR-CTSA mechanism for requesting biostatistics support
- Statistics and Methodology Core for the Vanderbilt Kennedy Center
- Daily walk-in Biostatistics Clinics
- Hourly fees for service
Consulting requests, whether for VICTR-CTSA biostatistics vouchers or otherwise, should be accompanied by this form
Funding Biostatistical Support
Percent efforts for biostatisticians on applications are readily accepted by grant reviewers and granting agencies, so it is common to have 0.15 - 0.5 FTEs allocated to biostatisticians (typically in a 2.5:1 ratio of MS:PhD effort) once a grant is awarded. Developing statistical designs and analysis plans for somewhat complex grants typically requires about 80 hours of biostatistician time. So that we can provide assistance with development of new grants (other than renewals or derivatives of grants that already fund a biostatistician) and data analysis and other services, there are several ways such services can be funded.
- By enrolling in the percent effort-based collaboration plan
- This plan allocates MS and PhD biostatistician percent efforts (typically in the 2.5:1 ratio) to work long-term with research groups, divisions, or departments. This approach makes it easy for the same statisticians to stay involved with a research group and facilitates the building of research teams and planning ahead for grant proposals, manuscripts, and abstract deadlines. It also helps our department plan its recruiting. Groups enrolling in this plan have 20% of the efforts of biostatisticians devoted to the research group paid by the Department of Biostatistics as long as the biostatisticians are doing work that is directly related to research development, teaching, or mentoring.
- We track time spent working with other departments on this plan so the other groups can make adjustments in percent efforts they fund over time and so that research group leaders know how the resource is being used.
- An excellent way to fund these efforts is for new faculty to include biostatistical support in their package.
- By fees for service (draft version)
- Unlike divisions or research groups enrolling in our collaboration plan in which we provide at least a 20% discount in salaries and fringe benefits covered, the fee for service plan involves the other division or research group paying for all salary, fringe benefits, a 25% overhead, and an additional amount depending on how much advance notice is given our faculty and staff to work on the project. Unlike project work, for grant proposal assistance, we charge by the hour using the same rate for all PhD and MS biostatisticians.
- For requests made more than 45 days before a deadline, the charge for grant proposal assistance for groups not taking part in our collaboration plan is $75 per hour.
- For emergency requests with a deadline within 4 days of the request (e.g., a grant proposal needing to be completed within 4 days of the biostatistician receiving a draft of the proposal) the hourly charge is tripled.
- For requests made between 45 days and 5 days of a deadline the additional charge factor varies from 1.0 to 2.5 according to the formula 2.6875 - 0.0375*d, where d is the number of days of advance notice.
- The Department will provide the PI with an estimate of the expected cost in advance, and a "not to exceed" cost. We will notify the PI before working more hours than the "not to exceed" cost covers.
- A grant proposal of average complexity with 45 days of advance notice requires about 50 hours of biostatistician time and costs the PI around $3750.
- For multi-department grant proposals, each group not subscribing to the collaboration plan will be billed separately in proportion to the work done specifically for planning that group's design and analysis.
Biostatistics Clinics
Need assistance with data analysis, study design, or how things are measured, displayed, or interpreted? The daily Biostatistics Clinics are here to help. Each day at noon (lunch provided), faculty in the Schools of Medicine and Nursing and in the Kennedy Center, other researchers, fellows, residents, and medical students may bring their quantitative and experimental design problems to the clinics and receive free help from a number of faculty and staff. Each clinic has a theme:
- Monday: General (including diagnostic and prognostic research)
- Tuesday: Omics Data (data in which there are more measurements than subjects; operated with the Dept. of Biomedical Informatics with participation of the Mass Spectrometry Research Center)
- Wednesday: Surgery, Anesthesiology, Emergency and Critical Care Medicine
- Thursday: Clinical Research (non-surgical; co-sponsored by GCRC; Room A3210 MCN)
- Friday: Basic Research
All clinics are held noon-1:15pm and all except for Thursday are held in MCN D2221. For more details visit http://biostat.mc.vanderbilt.edu/Clinics.
The Clinics are sponsored by the Dept. of Biostatistics, Vanderbilt Institute for Clinical and Translational Research (CTSA), Dept. of Biomedical Informatics, Clinical Research Center, Section of Surgical Sciences, School of Nursing, and the Vanderbilt Kennedy Center for Research on Human Development.
Who to Contact
If you are applying for assistance through VICTR (CTSA), apply for CTSA resources by going to https://www.mc.vanderbilt.edu/starbrite/funding.
Otherwise, if you would like more information or to arrange a meeting to discuss biostatistical support, contact Diane Kolb, Department of Biostatistics, at diane.kolb@vanderbilt.edu or 343-2227.
If your research group is already covered by a Biostatistics Collaboration Plan, contact the lead statistician who is responsible for your group. Assignments are listed at CollaborationAssignments.
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