Huiyun (William) Wu, Ph.D Assistant in Biostatistics
E-mail:   huiyun.wu@vanderbilt.edu Phone:  615.936.2788 Fax:      615.936.2602	Vanderbilt University School of Medicine Department of Biostatistics Vanderbilt-Ingram Cancer Center/Biostatistics Shared Resource Nashville, TN 37232-2158

Research Interests

• Statistical modeling of epidemilogic study.

• Nutrional epidemilogy and gene-nutrition interaction in cancer development.

• Statistical analysis of time to event data.

• Signal pathway and cancer.

Talks

• • Measurement error and measurement model(08/13/2005)
  • Slides

• • Mediation model
  • poster

• • gene-diet interaction
  • Slides

Membership

* American Heart Association

* American Society for Medical Informatics

publications

1. Fowler K, Poehling K, Billheimer D, Hamilton R, Wu H, et al. Hospice referral practices for children with cancer: a survey of pediatric oncologists. J Clin Oncol 2006;24:1099-104.

2. Cuneo KC, Geng L, Tan J, Wu H, et al. SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation. Int J Radiat Oncol Biol Phys 2006;64:1197-203.

3. Boyd AS, Wu H, Shyr Y. Monster cells in malignant melanoma. Am J Dermatopathol 2005;27:208-10.

4. Dwyer JH, Allayee H, Dwyer KM, Wu H, et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 2004;350:29-37.

5. Wu H, Dwyer KM, Fan Z, Shircore A, Fan J, Dwyer JH. Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Clin Nutr 2003;78:1085-91.

6. Xie S, Wu H, Wang Q, et al. Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2. Cell Cycle 2002;1:424-9.

7. Liby K, Wu H, Ouyang B, Wu S, Chen J, Dai W. Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. DNA Seq 2001;11:527-33.

8. Xie S, Wang Q, Wu H, et al. Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J Biol Chem 2001;276:36194-9.

9. Xie S, Wu H, Wang Q, et al. Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J Biol Chem 2001;276:43305-12.

10. Kang YJ, Wu H, Saari JT. Alterations in hypertrophic gene expression by dietary copper restriction in mouse heart. Proc Soc Exp Biol Med 2000;223:282-7.

11. Kang YJ, Zhou ZX, Wu H, Wang GW, Saari JT, Klein JB. Metallothionein inhibits myocardial apoptosis in copper- deficient mice: role of atrial natriuretic peptide. Lab Invest 2000;80:745-57.

12. Lan Z, Wu H, Li W, et al. Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. Blood 2000;95:633-8.

13. Wu H, Lan Z, Li W, et al. p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase. Oncogene 2000;19:4557-62.

14. Li W, Lan Z, Wu H, et al. BUBR1 phosphorylation is regulated during mitotic checkpoint activation. Cell Growth Differ 1999;10:769-75.

15. Wu HY, Kang YJ. Inhibition of buthionine sulfoximine-enhanced doxorubicin toxicity in metallothionein overexpressing transgenic mouse heart. J Pharmacol Exp Ther 1998;287:515-20.

16. Yin X, Wu H, Chen Y, Kang YJ. Induction of antioxidants by adriamycin in mouse heart. Biochem Pharmacol 1998;56:87-93.

17. Wu H, Xia YM, Ha PC, Chen XS. Changes in myocardial thyroid hormone metabolism and alpha-glycerophosphate dehydrogenase activity in rats deficient in iodine and selenium. Br J Nutr 1997;78:671-6.